지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2021.9
- 수록면
- 814 - 821 (8page)
- DOI
- 10.3349/ymj.2021.62.9.814
이용수
초록· 키워드
오류제보하기
Purpose: To evaluate whether vascular uptake on 18F-fluorodeoxyglucose positron emission tomography/computed tomography(18F-FDG PET/CT) during the clinically inactive state of Takayasu arteritis (TAK) is associated with disease relapse.
Materials and Methods: Patients with TAK who underwent 18F-FDG PET/CT during the clinically inactive state of the disease between2006 and 2019 were included. Clinically inactive disease was defined as a status not fulfilling the National Institutes of Health(NIH) criteria for active disease in TAK. Relapse was defined as recurrence of clinically active disease after a clinically inactive period,requiring change in the treatment regimen. Vascular uptake on 18F-FDG PET/CT was assessed using target/background ratio(TBR), calculated as arterial maximum standardized uptake value (SUV)/mean SUV in venous blood pool. Multivariable Coxregression analysis was performed to identify factors associated with relapse.
Results: A total of 33 patients with clinically inactive TAK were included. During a median observation period of 4.5 (0.9?8.1)years, relapse occurred in 9 (27.3%) patients at median 1.3 (0.7?6.9) years. Notably, TBR [1.5 (1.3?1.8) vs. 1.3 (1.1?1.4), p=0.044]was significantly higher in patients who relapsed than in those who did not. On multivariable Cox regression analysis, the presenceof NIH criterion 2 [adjusted hazard ratio (HR): 7.044 (1.424?34.855), p=0.017] and TBR [adjusted HR: 11.533 (1.053?126.282),p=0.045] were significantly associated with an increased risk of relapse.
Conclusion: Vascular uptake on 18F-FDG PET/CT and the presence of NIH criterion 2 are associated with future relapse in patientswith clinically inactive TAK.
목차
등록된 정보가 없습니다.
참고문헌 (3)
참고문헌 신청
Karapolat I / 2013 / Comparison of F18-FDG PET/CT findings with current clinical disease status in patients with Takayasu’s arteritis / Clin Exp Rheumatol 31(1 Suppl 75):S15~S21
Han Q / 2018 / An increased major vessel uptake by 18F-FDG-PET/CT in NIH criteria inactive patients with Takayasu’s arteritis / Clin Exp Rheumatol 36(2 Suppl 111):S88~S92
Hoffman GS / 1996 / Takayasu arteritis : lessons from the American National Institutes of Health experience / Int J Cardiol 54(Suppl):S99~S102
Han Q / 2018 / An increased major vessel uptake by 18F-FDG-PET/CT in NIH criteria inactive patients with Takayasu’s arteritis / Clin Exp Rheumatol 36(2 Suppl 111):S88~S92
Hoffman GS / 1996 / Takayasu arteritis : lessons from the American National Institutes of Health experience / Int J Cardiol 54(Suppl):S99~S102
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