지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2021.12
- 수록면
- 428 - 436 (9page)
이용수
초록· 키워드
오류제보하기
The aim of this study was to isolate and identify secondary metabolites from Sonchus brachyotus and evaluate their antioxidant and anti-inflammatory activities. In this study, we isolated three flavonoids from a 70% EtOH extract by Medium Pressure Liquid Chromatography (MPLC) and prep-High-Performance Liquid Chromatography (HPLC). To evaluate the biological activities (antioxidant and anti-inflammatory) of these flavonoids, their in vitro inhibitory activities against lipopolysaccharide (LPS)-induced reactive oxygen species (ROS) generation, nitric oxide (NO) production, and prostaglandin E2 (PGE2) secretion were determined. We successfully identified three flavonoids, namely luteolin (1), luteolin-7-O-β-D-glucoside (2), and luteolin-7-O-β-D-glucuronide (3) by spectral analyses. Luteolin (1) at 20 μg/mL inhibited ROS generation, NO production, and PGE2 secretion by 48.6%, 61.28% and 12.10%, respectively, and luteolin-7-O-β-D-glucoside (2) inhibited NO and PGE2 generation by 67.03% and 20.82%, respectively.
Luteolin (1) and luteolin-7-O-β-D-glucoside (2) showed similar anti-inflammatory activities; however, luteolin (1) was observed to be a stronger antioxidant. Besides antioxidant and anti-inflammatory activities, S. brachyotus extract containing luteolin (1) and luteolin- 7-O-β-D-glucoside (2) is considered to possess diverse biological activities. The results indicate that S. brachyotus is an edible medicinal plant, which is believed to be significant resource of functional foods.
목차
등록된 정보가 없습니다.
참고문헌 (31)
참고문헌 신청
Bai YH / 2008 / Chemical constituents of Japanese herb Sonchus oleraceus / J China Pharm Univ 39:279~281
Chanput W / 2016 / Anti-oxidative assays as markers for anti-inflammatory activity of flavonoids / Int Immunophamacol 40:170~175
Elkhayat ES / 2009 / Chemical and biological investigations of the roots of Sonchus oleraceus L. growing in Egypt / Bull Pharm Sci 32:189~197
Hendriani R / 2014 / In vitro evaluation of xanthine oxidase inhibitory activity of Sonchus arvensis leaves / Int J Pharm Clin Res 6:501~503
Huyan T / 2016 / Anti-tumor effect of hot aqueous extracts from Sonchus oleraceus (L.) L. and Juniperus sabina L – two traditional medicinal plants in China / J Ethnopharmacol 185:289~299
Chanput W / 2016 / Anti-oxidative assays as markers for anti-inflammatory activity of flavonoids / Int Immunophamacol 40:170~175
Elkhayat ES / 2009 / Chemical and biological investigations of the roots of Sonchus oleraceus L. growing in Egypt / Bull Pharm Sci 32:189~197
Hendriani R / 2014 / In vitro evaluation of xanthine oxidase inhibitory activity of Sonchus arvensis leaves / Int J Pharm Clin Res 6:501~503
Huyan T / 2016 / Anti-tumor effect of hot aqueous extracts from Sonchus oleraceus (L.) L. and Juniperus sabina L – two traditional medicinal plants in China / J Ethnopharmacol 185:289~299
함께 읽어보면 좋을 논문
논문 유사도에 따라 DBpia 가 추천하는 논문입니다. 함께 보면 좋을 연관 논문을 확인해보세요!
-
건조 방법에 따른 환삼덩굴 추출물 중 Luteolin 유도체의 함량 변화
한국약용작물학회지
2023 .12
-
Rosmarinic acid와 luteolin의 항염증에 대한 상승효과
한국식품과학회지
2015 .02
-
Comparison of Phase II Enzymes Activities of Luteolin and Luteolin-7-O-Glucoside Against GalN/LPS Induced Hepatitic ICR Mice
한국식품영양과학회 학술대회발표집
2018 .10
-
유통 채소류의 아피제닌 및 루테올린 함량 조사
한국식품영양학회지
2021 .01
-
Anti-proliferation Effect of Quercetin and Luteolin Derivatives in B16F0, Mouse Melanoma
한국식품영양과학회 학술대회발표집
2021 .10
-
Anti-inflammatory Effect of Luteolin Derivative, YJ-Q-337 in LPS-stimulated RAW 264.7 Cells
한국식품영양과학회 학술대회발표집
2023 .10
-
Tissue Specific Action of PPARγ as a Mediator of the Metabolic Response to Flavonoid Luteolin in Diet-Induced Obesity
한국식품영양과학회 학술대회발표집
2016 .10
-
차풀 추출물의 항산화 활성 및 지표성분 분석
한국식품영양과학회지
2025 .02
-
Synergistic Effect of Luteolin and Fisetin on Inflammation under Diabetic Condition In Vitro
한국식품영양과학회 학술대회발표집
2015 .08
-
Radiolytic Luteolin Derivative Exhibits Anti-Inflammatory Actions in Bone Marrow-Derived Dendritic Cells
한국식품영양과학회 학술대회발표집
2018 .10
-
Evaluation of biological activities of Sonchus brachyotus
한국수산과학회 양식분과 학술대회
2016 .05
-
Actions of Luteolin on Regulation of Overweight Metabolic Stress through the Interplay between the Liver and Adipose Tissue
한국식품영양과학회 학술대회발표집
2018 .10
-
Anti-inflammatory effects of luteolin and luteoloside from Taraxacum coreanum in RAW264.7 macrophage cells
Applied Biological Chemistry
2016 .01
-
Erratum to: Anti-inflammatory effects of luteolin and luteoloside from Taraxacum coreanum in RAW264.7 macrophage cells
Applied Biological Chemistry
2016 .01
-
도라지 잎 에탄올 추출물의 주요 성분 분석 및 마우스 대식세포와 인체 폐암세포에서 항염효과
한국식품영양학회지
2024 .04
-
Analysis of Luteolin in Deodeok (Codonopsis lanceolata) Young Leaf for Food Processing Materials
한국식품영양과학회 학술대회발표집
2019 .10
-
Protective Effects of Flavone Luteolin on Obese Sarcopenia in Mice with High-fat Diet-induced Obesity
한국식품영양과학회 학술대회발표집
2022 .10
-
감국 발효 열수 추출물의 에탄올에 의해 손상된 HepG2 세포의 간보호 효과
한국식품과학회지
2021 .06
-
Luteolin and apigenin inhibits itch-related IL-31 and IL-33 cytokines in mouse astrocytes
한국식품영양과학회 학술대회발표집
2019 .10
-
Determination of luteolin 7-glucuronide in Perilla frutescens (L.) Britt. leaf extracts from different regions of China and South Korea and its cholesterol-lowering effect
한국식품영양과학회 학술대회발표집
2023 .10
이 논문의 저자 정보
최근 본 자료
댓글(0)
0