Effect of parasitic infection on muscular function of dystrophin gene (Dmd) deficient mouse

Shin Ha Rim; Ko Eun-Ji; Kang Yun-Jeong; Yu Hak-Sun; Ock Mee Sun; Cha Hee-Jae

doi:10.1007/s13258-022-01355-5

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저자정보: Shin Ha Rim (University of Ulsan College of Medicine) Ko Eun-Ji (Kosin University College of Medicine) Kang Yun-Jeong (Kosin University College of Medicine) Yu Hak-Sun (Pusan National University) Ock Mee Sun (Kosin University College of Medicine) Cha Hee-Jae (Kosin University College of Medicine)

저널정보: 한국유전학회 Genes & Genomics Genes & Genomics Vol.45 No.2

발행연도: 2023.2

수록면: 183 - 190 (8page)

DOI: 10.1007/s13258-022-01355-5

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Background Previous studies have reported many cases of Trichinella spiralis (T. spiralis) infection in normal skeletal muscle but there is little research on T. spiralis infection in abnormal muscle tissue. Objective To identify the effect of T. spiralis infection on muscular dystrophy, this study compared aspects of infection between normal (C57BL/10) and dystrophin-deficient Duchenne muscular dystrophy (DMD) mdx mice. Method Infection rate was found to be lower in mdx mice than in C57BL/10 mice at early stages of infection; however, infection and inflammation in mdx mice persisted at later stages of infection while the infection rate and inflammation in C57BL/10 mice decreased gradually. The inflammation area was proportional to the degree of infection in both groups. Muscle strength was measured by the time of latency to fall in the wire-hanging test. Hanging time was shorter in the infected group than in the uninfected group in both C57BL/10 and mdx mice. Results Muscle strength was also reduced in mdx mice compared with C57BL/10 mice in both the un-infected and infected groups. The muscle intracellular cytokines TGF-β and IL-6 were continuously expressed from early stage to late-stage infection. IL-10 was strongly expressed at the early stage of infection but decreased as the infection progressed. TNF-α expression remained stable from early to late-stage infection in mdx mice, while TNF-α was elevated only during early-stage infection in C57BL/10 mice. The degree of muscle damage was significantly higher in mdx mice than in C57BL/10 mice because of the high level of serum creatine kinase (CK). Conclusion These results suggest that mdx mice continued in infection and inflammation until the late stages of disease, which was in contrast to the C57BL/10 mice that recovered to some extent in the late stage of infection. In addition, that dystrophin-deficient mice are not suitable for T. spiralis infection compared to normal mice, and the degree of inflammation may be worse in mdx mice.

Background Previous studies have reported many cases of Trichinella spiralis (T. spiralis) infection in normal skeletal muscle but there is little research on T. spiralis infection in abnormal muscle tissue. Objective To identify the effect of T. spiralis infection on muscular dystrophy, this study compared aspects of infection between normal (C57BL/10) and dystrophin-deficient Duchenne muscular dystrophy (DMD) mdx mice. Method Infection rate was found to be lower in mdx mice than in C57BL/10 mice at early stages of infection; however, infection and inflammation in mdx mice persisted at later stages of infection while the infection rate and inflammation in C57BL/10 mice decreased gradually. The inflammation area was proportional to the degree of infection in both groups. Muscle strength was measured by the time of latency to fall in the wire-hanging test. Hanging time was shorter in the infected group than in the uninfected group in both C57BL/10 and mdx mice. Results Muscle strength was also reduced in mdx mice compared with C57BL/10 mice in both the un-infected and infected groups. The muscle intracellular cytokines TGF-β and IL-6 were continuously expressed from early stage to late-stage infection. IL-10 was strongly expressed at the early stage of infection but decreased as the infection progressed. TNF-α expression remained stable from early to late-stage infection in mdx mice, while TNF-α was elevated only during early-stage infection in C57BL/10 mice. The degree of muscle damage was significantly higher in mdx mice than in C57BL/10 mice because of the high level of serum creatine kinase (CK). Conclusion These results suggest that mdx mice continued in infection and inflammation until the late stages of disease, which was in contrast to the C57BL/10 mice that recovered to some extent in the late stage of infection. In addition, that dystrophin-deficient mice are not suitable for T. spiralis infection compared to normal mice, and the degree of inflammation may be worse in mdx mice.

#Cytokine · Trichinella spiralis · Mdx mice · Muscular dystrophy · Infection

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Shin Ha Rim

소속기관 University of Ulsan College of Medicine

주요연구분야 자연과학 > 생물학 자연과학 > 화학

논문수 2 이용수 4

Ko Eun-Ji

소속기관 Kosin University College of Medicine

주요연구분야 자연과학 > 기타 자연과학 의약학 > 의학 일반

논문수 16 이용수 737

Kang Yun-Jeong

소속기관 Kosin University College of Medicine

주요연구분야 자연과학 > 생물학

논문수 1 이용수 0

Yu Hak-Sun

소속기관 부산대학교

주요연구분야 자연과학 > 생물학

논문수 1 이용수 0

Ock Mee Sun

소속기관 Kosin University College of Medicine

주요연구분야 자연과학 > 생물학

논문수 2 이용수 2

Cha Hee-Jae

소속기관 Kosin University College of Medicine

주요연구분야 의약학 > 의학 일반 자연과학 > 생물학

논문수 4 이용수 3

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