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논문 기본 정보

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학술저널
저자정보
Sung-Soo Park (Department of Hematology, Catholic Hematology Hospital, Seoul St. Mary’s Hospital, College of Medic) Hee-Je Kim (Department of Hematology, Catholic Hematology Hospital, Seoul St. Mary’s Hospital, College of Medic) Tong Yoon Kim (Department of Hematology, Catholic Hematology Hospital, Seoul St. Mary’s Hospital, College of Medic) Joon yeop Lee (Department of Hematology, Catholic Hematology Hospital, Seoul St. Mary’s Hospital, College of Medic) Jong Hyuk Lee (Department of Hematology, Catholic Hematology Hospital, Seoul St. Mary’s Hospital, College of Medic) Gi June Min (Department of Hematology, Catholic Hematology Hospital, Seoul St. Mary’s Hospital, College of Medic) Silvia Park (Department of Hematology, Catholic Hematology Hospital, Seoul St. Mary’s Hospital, College of Medic) Jae-Ho Yoon (Department of Hematology, Catholic Hematology Hospital, Seoul St. Mary’s Hospital, College of Medic) Sung-Eun Lee (Department of Hematology, Catholic Hematology Hospital, Seoul St. Mary’s Hospital, College of Medic) Byung-Sik Cho (Department of Hematology, Catholic Hematology Hospital, Seoul St. Mary’s Hospital, College of Medic) Ki-Seong Eom (Department of Hematology, Catholic Hematology Hospital, Seoul St. Mary’s Hospital, College of Medic) Yoo-Jin Kim (Department of Hematology, Catholic Hematology Hospital, Seoul St. Mary’s Hospital, College of Medic) Seok Lee (Department of Hematology, Catholic Hematology Hospital, Seoul St. Mary’s Hospital, College of Medic) Dong-Wook Kim (Department of Hematology, Catholic Hematology Hospital, Seoul St. Mary’s Hospital, College of Medic)
저널정보
대한혈액학회 Blood Research Blood Research Vol.56 No.3
발행연도
2021.9
수록면
184 - 196 (13page)
DOI
10.5045/br.2021.2021107

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Background Allogeneic hematopoietic stem cell transplantation (alloSCT) is a potentially curative treatment option for acute leukemia. We aimed to identify the comorbidity factors affecting survival outcomes after alloSCT and develop a new comorbidity index tool for predicting overall survival (OS). Methods A Korean nationwide cohort of 3,809 adults with acute leukemia treated with alloSCT between January 2002 and December 2018 was analyzed as the development cohort. A retrospective cohort comprising 313 consecutive adults with acute leukemia who underwent alloSCT between January 2019 and April 2020 was analyzed as the validation cohort. Results In the development cohort, advanced age, male sex, and comorbidities such as previous non-hematologic malignancy, hypertension, and coronary or cerebral vascular disease were significantly related to poor OS. Subsequently, a new comorbidity scoring system was developed, and risk groups were created, which included the low-risk (score ≤0.17), intermediate-risk (0.17＜ score ≤0.4), high-risk (0.4＜ score ≤0.55), and very high-risk (score ＞0.55) groups. The 1-year OS rates were discriminatively estimated at 73.5%, 66.2%, 61.9%, and 50.9% in the low-risk, intermediate-risk, high-risk, and very high-risk groups in the development cohort, respectively (P＜0.001). The developed scoring system yielded discriminatively different 1-year OS rates and 1-year incidence of non-relapse mortality according to the risk group (P=0.085 and P=0.018, respectively). Furthermore, the developed model showed an acceptable performance for predicting 1-year non-relapse mortality with an area under the curve of 0.715. Conclusion The newly developed predictive scoring system could be a simple and reliable tool helping clinicians to assess risk of alloSCT in adults with acute leukemia.
#Comorbidity #Allogeneic #Transplantation #Stem cell #Acute leukemia #Score

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참고문헌 (20)

참고문헌 신청
Mukherjee S / 2019 / Novel therapies in acute myeloid leukemia / Semin Oncol Nurs 35:150955 google schola Samra B / 2020 / Evolving therapy of adult acute lymphoblastic leukemia : state-of-the-art treatment and future directions / J Hematol Oncol 13:70 google schola Tallman MS / 2019 / Acute myeloid leukemia, version 3.2019, NCCN Clinical Practice Guidelines in Oncology / J Natl Compr Canc Netw 17:721~749 google schola Yoon JH / 2017 / Long-term clinical outcomes of hematopoietic cell transplantation for intermediate-to-poor-risk acute myeloid leukemia during first remission according to available donor types / Oncotarget 8:41590~41604 google schola Yoon JH / 2016 / Minimal residual disease-based effect and long-term outcome of first-line dasatinib combined with chemotherapy for adult Philadelphia chromosome-positive acute lymphoblastic leukemia / Ann Oncol 27:1081~1088 google schola

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