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논문 기본 정보

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Gaurav Prakash (Postgraduate Institute of Medical Education and Research, Chandigarh, India) Arihant Jain (Postgraduate Institute of Medical Education and Research, Chandigarh, India) Kamalkant Sahu (Postgraduate Institute of Medical Education and Research, Chandigarh, India) Amanjit Bal (Postgraduate Institute of Medical Education and Research, Chandigarh, India) Charanpreet Singh (Postgraduate Institute of Medical Education and Research, Chandigarh, India) Rajender Basher (Postgraduate Institute of Medical Education and Research, Chandigarh, India) Harmandeep Singh (Postgraduate Institute of Medical Education and Research, Chandigarh, India) Kundan Mishra (Postgraduate Institute of Medical Education and Research, Chandigarh, India) Aditya Jandial (Postgraduate Institute of Medical Education and Research, Chandigarh, India) Deepesh Lad (Postgraduate Institute of Medical Education and Research, Chandigarh, India) Alka Khadwal (Postgraduate Institute of Medical Education and Research, Chandigarh, India) Radhika Srinivasan (Postgraduate Institute of Medical Education and Research, Chandigarh, India) Ashim Das (Postgraduate Institute of Medical Education and Research, Chandigarh, India) Neelam Varma (Postgraduate Institute of Medical Education and Research, Chandigarh, India) Subhash Varma (Postgraduate Institute of Medical Education and Research, Chandigarh, India) Pankaj Malhotra (Postgraduate Institute of Medical Education and Research, Chandigarh, India)
저널정보
대한혈액학회 Blood Research Blood Research Vol.56 No.3
발행연도
2021.9
수록면
134 - 140 (7page)
DOI
10.5045/br.2021.2021039

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Background This study evaluated the outcomes of patients with refractory/relapsed Hodgkin lymphoma (RRHL) treated with a bendamustine-based regimen in combination with ifosfamide, etoposide, and vinorelbine (VIBE). Methods Consecutive RRHL patients who were treated with the VIBE regimen were identified and studied for clinicopathologic characteristics, response to VIBE regimen, event-free survival (EFS), and feasibility of an autologous stem-cell transplant (autoSCT). Results In total, 24 patients received the VIBE regimen, and a median of 3 cycles were administered. In this cohort, 80% of the patients had received ≥2 prior lines of therapy. The overall and complete response rates with VIBE were 79% and 42%, respectively. After a median follow-up (following VIBE regimen) of 14 months (range, 3?76), the 3-year EFS and OS were 46% and 74%, respectively. Of the eligible patients, 92% underwent successful AutoSCT. The mean CD34+ cell count in the autograft was 5.5×106 /kg (SD 2.07). Neutropenia was the commonest hematologic toxicity and it was observed in 42% of the patients. However, only 9% of the patients developed grade III/IV febrile neutropenia. Chemotherapy-induced nausea and vomiting were the second most common grade III/IV toxicities in our cohort of patients. Conclusion In this retrospective analysis, the combination regimen, VIBE, has shown good efficacy in heavily pre-treated patients with RRHL without compromising stem cell collection. These encouraging results provide a rationale for further development of this regimen.
#Relapsed refractory #Hodgkin Lymphoma #Salvage #Bendamustine #Autologous transplant

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참고문헌 (17)

참고문헌 신청
Canellos GP / 2014 / Treatment of Hodgkin lymphoma : a 50-year perspective / J Clin Oncol 32:163~168 google schola Straus DJ / 2004 / Results of a prospective randomized clinical trial of doxorubicin, bleomycin, vinblastine, and dacarbazine(ABVD)followed by radiation therapy(RT)versus ABVD alone for stages I, II, and IIIA nonbulky Hodgkin disease / Blood 104:3483~3489 google schola Hertzberg MS / 2003 / Outpatient-based ifosfamide, carboplatin and etoposide(ICE)chemotherapy in transplant-eligible patients with non-Hodgkin’s lymphoma and Hodgkin’s disease / Ann Oncol 14(Suppl 1):i11~i16 google schola Abali H / 2008 / Comparison of ICE(ifosfamide-carboplatin-etoposide)versus DHAP(cytosine arabinoside-cisplatin-dexamethasone)as salvage chemotherapy in patients with relapsed or refractory lymphoma / Cancer Invest 26:401~406 google schola Bartlett NL / 2007 / Gemcitabine, vinorelbine, and pegylated liposomal doxorubicin(GVD), a salvage regimen in relapsed Hodgkin’s lymphoma : CALGB 59804 / Ann Oncol 18:1071~1079 google schola

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