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자료유형
학술저널
저자정보
Woojung Jeon (Department of Pediatrics University of Ulsan College of Medicine Asan Medical Center Seoul Korea) Young Kwon Koh (Department of Pediatrics University of Ulsan College of Medicine Asan Medical Center Seoul Korea) Sunghan Kang (Department of Pediatrics University of Ulsan College of Medicine Asan Medical Center Seoul Korea) Hyery Kim (Department of Pediatrics University of Ulsan College of Medicine Asan Medical Center Seoul Korea) Kyung-Nam Koh (Department of Pediatrics University of Ulsan College of Medicine Asan Medical Center Seoul Korea) Ho Joon Im (Department of Pediatrics University of Ulsan College of Medicine Asan Medical Center Seoul Korea)
저널정보
대한혈액학회 Blood Research Blood Research Vol.57 No.1
발행연도
2022.3
수록면
41 - 50 (10page)
DOI
10.5045/br.2021.2021164

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Background Aggressive mature B-cell non-Hodgkin lymphoma (B-NHL) is the most common non-Hodgkin lymphoma in children. The outcome of chemotherapy for B-NHL has improved over decades. Methods We reviewed 82 children and adolescents with B-NHL diagnosed at Asan Medical Center between 1993 and 2020. The D-COMP/COMP (daunomycin?cyclophosphamide, doxorubicin, vincristine, and prednisolone), Pediatric Oncology Group (POG)-9219/9315/ 9317, R-CHOP/CHOP (rituximab?cyclophosphamide, doxorubicin, vincristine, and prednisolone), and Lymphomes Malins B 89 (LMB89)/LMB96 regimens were administered. In 2018, rituximab was added to the LMB protocol (R-LMB) for advanced- staged Burkitt lymphoma (BL). The patients’ clinical features and treatment outcomes were retrospectively analyzed. Results The most common subtype was BL (61%), followed by diffuse large B-cell lymphoma (DLBCL) (35%). The median age was 7.8 (range, 1.3?16.4) years, and the most frequently used regimen was French?American?British (FAB)/LMB96 (58 patients, 70.7%). The 5-year overall survival (OS) and event-free survival (EFS) rates were 92.5% and 85.7%, respectively. The EFS rates of patients with BL and DLBCL were 90.0% and 79.3%, respectively. Among the FAB/LMB risk groups, group C (85.7%) had a significantly lower 5-year OS (P =0.037). Eleven events occurred (6 relapses, 3 deaths, and 2 secondary malignancies) during the median follow-up of 7.1 (range, 3.7?118.5) months. Two patients treated with R-LMB had good outcomes without complications. Conclusion Various treatment regimens have favorable outcomes in pediatric patients with B-NHL. However, further studies are needed to improve survival in high-risk patients. In addition, careful monitoring for acute toxicity or secondary malignancy due to intensive multidrug chemotherapy is required.

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