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논문 기본 정보

자료유형
학술저널
저자정보
Ya-Jun Li (Central South University Changsha) Ji-Wei Li (Fudan University Shanghai Cancer Center) Kai-Lin Chen (Central South University Changsha) Jin Li (Central South University Changsha) Mei-Zuo Zhong (Xiangya Hospital) Xian-Ling Liu (Central South University Changsha) Ping-Yong Yi (Central South University Changsha) Hui Zhou (Central South University Changsha)
저널정보
대한혈액학회 Blood Research Blood Research Vol.55 No.1
발행연도
2020.1
수록면
49 - 56 (8page)

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BackgroundHuman immunodeficiency virus (HIV)-negative plasmablastic lymphoma (PBL) is a rare entity of diffuse large B-cell lymphoma (DLBCL). The clinicopathological features of and optimal treatment for HIV-negative PBL remain largely unknown.MethodsTo gain insight into this distinct lymphoma, we summarized the clinicopathologic charac-teristics of 8 unpublished HIV-negative PBLs and performed a comprehensive review of 394 published cases.ResultsOf the 8 unpublished PBLs, the median patient age was 53.0 years. Four patients pre-sented with stage IV disease. All 8 patients showed a plasma cell-like immunophenotype. Of the six patients who received anthracycline-based chemotherapy, including two who received bortezomib, three patients achieved a continuous complete response, two pa-tients died due to disease progression, and one patient was lost to follow-up. The other two patients achieved continuous complete response after receiving chemotherapy com-bined with radiotherapy and surgery. Of the 402 patients, the majority were male, with a mean age of 58.0 years. EBV infection was detected in 55.7% of the patients. The median survival times of the patients who received CHOP or CHOP-like regimens and intensive regimens were not reached and 23.0 months, respectively, and the intensive regimen did not improve the survival outcome (P=0.981). Multivariate analysis showed that EBER remained the only independent factor affecting overall survival (OS).ConclusionHIV-negative PBL is a distinct entity with a predilection for elderly and immunosup-pressed individuals. Intensive chemotherapy had no apparent survival benefits over the CHOP regimen in terms of OS; the prognosis of this disease is poor with current chemo-therapy methods, and treatment remains a challenge.
#Clinicopathological features #Plasmablastic lymphoma #HIV negative #Treatment #Prognosis

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참고문헌 (39)

참고문헌 신청
Campo E / 2011 / The 2008 WHO classification of lymphoid neoplasms and beyond : evolving concepts and practical applications / Blood 117:5019~5032 google schola Gu X / 2018 / Interactions between life expectancy and the incidence and mortality rates of cancer in China : a population-based cluster analysis / Cancer Commun(Lond) 38:44 google schola Saba NS / 2013 / Bortezomib in plasmablastic lymphoma : a case report and review of the literature / Onkologie 36:287~291 google schola Cao C / 2014 / Bortezomibcontained chemotherapy and thalidomide combined with CHOP(Cyclophosphamide, Doxorubicin, Vincristine, and Prednisone)play promising roles in plasmablastic lymphoma : a case report and literature review / Clin Lymphoma Myeloma Leuk 14:e145~50 google schola Yan M / 2014 / CD20-positive plasmablastic lymphoma with excellent response to bortezomib combined with rituximab / Eur J Haematol 93:77~80 google schola

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