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학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2021.11
- 수록면
- 1,397 - 1,410 (14page)
- DOI
- 10.5187/jast.2021.e125
이용수
초록· 키워드
오류제보하기
The present study was designed to determine the influence of all-trans retinoic acid (ATRA) on adipogenesis-related gene regulation in bovine intramuscular (IM) and subcutaneous (SC) adipose cells during differentiation. Bovine IM and SC adipocytes were isolated from three 19-mo-old, crossbred steers. Adipogenic differentiation was induced upon cultured IM and SC preadipocytes with various doses (0, 0.001, 0.01, 0.1, 1 μM) of ATRA. After 96 h of incubation, cells were harvested and used to measure the gene expression of CCAAT/Enhancer binding protein β (C/EBPβ), peroxisome proliferator-activated receptor (PPAR) γ, glucose transporter 4 (GLUT4), stearoyl CoA desaturase (SCD), and Smad transcription factor 3 (Smad3) relative to the quantity of ribosomal protein subunit 9 (RPS 9). Retinoic acid receptor (RAR) antagonist also tested to identify the effect of ATRA on PPARγ -RAR related gene expression in IM cells. The addition of ATRA to bovine IM decreased (p < 0.05) expression of PPARγ. The expression of PPARγ was also tended to be downregulated (p < 0.1) in high levels (10 μM) of ATRA treatment in SC cells. The treatment of RAR antagonist increased the expression of PPARγ in IM cells. Expression of C/EBPβ decreased (p < 0.05) in SC, but no change was observed in IM (p > 0.05). Increasing levels of ATRA may block adipogenic differentiation via transcriptional regulation of PPARγ. The efficacy of ATRA treatment in adipose cells may vary depending on the location.
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등록된 정보가 없습니다.
참고문헌 (38)
참고문헌 신청
National Academies of Sciences / 2016 / Engineering, and Medicine. Nutrient requirements of beef cattle / The National Academies Press
Smith SB / 2007 / Marbling: management of cattle to maximize the deposition of intramuscular adipose tissue / Plains Nutrition Council Spring Conference
F Villarroya / 1999 / Retinoids and adipose tissues: metabolism, cell differentiation and gene expression / International Journal of Obesity 23(1):1~6
Hausman GJ / 2009 / Applied muscle biology and meat science / CRC Press :67~80
McDowell LR / 2008 / Vitamins in animal and human nutrition / Iowa State University Press
Smith SB / 2007 / Marbling: management of cattle to maximize the deposition of intramuscular adipose tissue / Plains Nutrition Council Spring Conference
F Villarroya / 1999 / Retinoids and adipose tissues: metabolism, cell differentiation and gene expression / International Journal of Obesity 23(1):1~6
Hausman GJ / 2009 / Applied muscle biology and meat science / CRC Press :67~80
McDowell LR / 2008 / Vitamins in animal and human nutrition / Iowa State University Press
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