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학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2021.11
- 수록면
- 1,247 - 1,264 (18page)
- DOI
- 10.5187/jast.2021.e102
이용수
초록· 키워드
오류제보하기
Anabolic steroids are frequently used to increase the growth rate of meat-producing animals. Exposure to an anabolic-androgenic steroid, nandrolone decanoate (ND), is associated with expressional reduction of testicular steroidogenic enzymes. However, the effect of withdrawal of ND exposure on the expression of these testicular molecules has not been thoroughly explored. The current research investigated expression changes of testicular steroidogenic enzymes in rats at several recovery periods (2, 6, and 12 weeks) after the stop of ND treatment with different doses (2 and 10 mg/kg body weight) for 12 weeks. Body and testis weights were recorded, and transcript levels of molecules were determined by quantitative real-time polymerase chain reaction (PCR). The immunohistochemistry was used to examine the changes of immuno-intensities of molecules. At 6 and 12 weeks of the recovery period, the 10 mg/kg ND-treated rats were lighter than other experimental groups. The interstitial compartment vanished by ND treatment filled up as the recovery period became longer. The expression of steroidogenic acute regulatory protein was returned to the control level at 12 weeks of the recovery period. Expression levels of cytochrome P450 sidechain cleavage and 17a-hydroxylase were increased in 2 mg/kg ND-treated group at 6 weeks of the recovery period, and transcript levels of these molecules in 2 and 10 mg/kg ND-treated groups at 12 weeks of the recovery period were significantly lower than the control. Expression levels of 3β-hydroxysteroid dehydrogenase (HSD) type I and 17β-HSD type 3 in 2 mg/kg ND-treated group were comparable with those of control at 12 weeks of the recovery period, but not in 10 mg/kg ND-treated group. Expression of cytochrome P450 aromatase (Cyp19) was reverted to the control level at 2 weeks of the recovery period. Except for Cyp19, there was a visible increase of immuno- staining intensity of other testicular steroidogenic enzymes in the Leydig cells as the recovery period progressed. This research has demonstrated that the cease of ND administration could restore the expression of testicular steroidogenic enzymes close to the normal level. Nevertheless, a relatively long recovery period, compared to the ND-exposure period would be required to retrieve normal expression levels of testicular steroidogenic enzymes.
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등록된 정보가 없습니다.
참고문헌 (29)
참고문헌 신청
E.W. Bergink / 1985 / Comparison of the receptor binding properties of nandrolone and testosterone under in vitro and in vivo conditions / Journal of Steroid Biochemistry 22(6):831~836
Franz Schwarzenberger / 1993 / Plasma levels of several androgens and estrogens from birth to puberty in male domestic pigs / Acta Endocrinologica 128(2):173~177
Katia De Wasch / 2001 / Consequence of boar edible tissue consumption on urinary profiles of nandrolone metabolites. II. Identification and quantification of 19-norsteroids responsible for 19-norandrosterone and 19-noretiocholanolone excretion in human urine / Rapid Communications in Mass Spectrometry 15(16):1442~1447
Francesco Busardo / 2015 / The Impact of Nandrolone Decanoate on the Central Nervous System / Current Neuropharmacology 13(1):122~131
Federico Giuseppe Patanè / 2020 / Nandrolone Decanoate: Use, Abuse and Side Effects / Medicina 56(11):606
Franz Schwarzenberger / 1993 / Plasma levels of several androgens and estrogens from birth to puberty in male domestic pigs / Acta Endocrinologica 128(2):173~177
Katia De Wasch / 2001 / Consequence of boar edible tissue consumption on urinary profiles of nandrolone metabolites. II. Identification and quantification of 19-norsteroids responsible for 19-norandrosterone and 19-noretiocholanolone excretion in human urine / Rapid Communications in Mass Spectrometry 15(16):1442~1447
Francesco Busardo / 2015 / The Impact of Nandrolone Decanoate on the Central Nervous System / Current Neuropharmacology 13(1):122~131
Federico Giuseppe Patanè / 2020 / Nandrolone Decanoate: Use, Abuse and Side Effects / Medicina 56(11):606
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