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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2021.9
- 수록면
- 984 - 997 (14page)
- DOI
- 10.5187/jast.2021.e90
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초록· 키워드
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This study sought to evaluate DNA damage and repair in porcine postovulatory aged oocytes. The DNA damage response, which was assessed by H2A.X expression, increased in porcine aged oocytes over time. However, the aged oocytes exhibited a significant decrease in the expression of RAD51, which reflects the DNA damage repair capacity. Further experiments suggested that the DNA repair ability was suppressed by the downregulation of genes involved in the homologous recombination (HR) and nonhomologous end-joining (NHEJ) pathways. The expression levels of the cell cycle checkpoint genes, CHEK1 and CHEK2, were upregulated in porcine aged oocytes in response to induced DNA damage. Immunofluorescence results revealed that the expression level of H3K79me2 was significantly lower in porcine aged oocytes than in control oocytes. In addition, embryo quality was significantly reduced in aged oocytes, as assessed by measuring the cell proliferation capacity. Our results provide evidence that DNA damage is increased and the DNA repair ability is suppressed in porcine aged oocytes. These findings increase our understanding of the events that occur during postovulatory oocyte aging.
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참고문헌 (50)
참고문헌 신청
Shao-Chen Sun / 2012 / Degradation of actin nucleators affects cortical polarity of aged mouse oocytes / Fertility and Sterility 97(4):984~990
Qiu-Xia Liang / 2018 / Resveratrol increases resistance of mouse oocytes to postovulatory aging in vivo / Aging 10(7):1586~1596
Yue Wang / 2019 / N-acetyl-L-cysteine (NAC) delays post-ovulatory oocyte aging in mouse / Aging 11(7):2020~2030
Y.-L. Miao / 2009 / Oocyte aging: cellular and molecular changes, developmental potential and reversal possibility / Human Reproduction Update 15(5):573~585
Michael J. Bertoldo / 2020 / NAD+ Repletion Rescues Female Fertility during Reproductive Aging / Cell Reports 30(6):1670~1681
Qiu-Xia Liang / 2018 / Resveratrol increases resistance of mouse oocytes to postovulatory aging in vivo / Aging 10(7):1586~1596
Yue Wang / 2019 / N-acetyl-L-cysteine (NAC) delays post-ovulatory oocyte aging in mouse / Aging 11(7):2020~2030
Y.-L. Miao / 2009 / Oocyte aging: cellular and molecular changes, developmental potential and reversal possibility / Human Reproduction Update 15(5):573~585
Michael J. Bertoldo / 2020 / NAD+ Repletion Rescues Female Fertility during Reproductive Aging / Cell Reports 30(6):1670~1681
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