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학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2021.9
- 수록면
- 977 - 983 (7page)
- DOI
- 10.5187/jast.2021.e86
이용수
초록· 키워드
오류제보하기
Closely correlated expression patterns between ubiquitin specific peptidase 9X-linked (USP9X) and adherens junction formation factor (Afadin) in mouse testis development suggests that Usp9x regulates the deubiquitination of Af-6 (also known as Afadin, AFDN), and subsequently, the cell adhesion dynamics during gametogenesis. However, this relationship has not yet been tested in other domestic animals. The study was examined the temporal and spatial expression patterns of porcine USP9X and AFDN from the pre-pubertal to adult stages using real time-PCR and immunohistochemistry. Furthermore, we detected the transcripts of USP9X and AFDN in the testis of 1-, 6- and 12-months old boar, respectively. USP9X and AFDN were found to have similar expressions patterns, with basal expression after 1 month followed by a significant up-regulation from 6 months (puberty) onwards. In addition, neither the AFDN or USP9X proteins were detected in spermatogenic cells but they were expressed in the leydig cells and sertoli cells. USP9X was detected around the basal lamina during pre-puberty, and predominantly expressed in the leydig cells at puberty. Finally, in adult testis, USP9X was increased at the sertoli cell-cell interface and the sertoli cell-spermatid interface. In summary, closely correlated expression patterns between USP9X and AFDN in boar testis supports the previous findings in mice. Furthermore, the junction connections between the sertoli cells may be regulated by the ubiquitination process mediated via USP9X.
목차
등록된 정보가 없습니다.
참고문헌 (17)
참고문헌 신청
Avram Hershko / 1998 / THE UBIQUITIN SYSTEM / Annual Review of Biochemistry 67(1):425~479
Mark Hochstrasser / 1995 / Ubiquitin, proteasomes, and the regulation of intracellular protein degradation / Current Opinion in Cell Biology 7(2):215~223
Rohini Bose / 2014 / Ubiquitin–Proteasome System in Spermatogenesis / Advances in Experimental Medicine and Biology 759:181~213
Bharathi Suresh / 2015 / The role of deubiquitinating enzymes in spermatogenesis / Cellular and Molecular Life Sciences 72(24):4711~4720
Takeshi Sato / 2004 / A close correlation in the expression patterns of Af-6 and Usp9x in Sertoli and granulosa cells of mouse testis and ovary / Reproduction 128(5):583~594
Mark Hochstrasser / 1995 / Ubiquitin, proteasomes, and the regulation of intracellular protein degradation / Current Opinion in Cell Biology 7(2):215~223
Rohini Bose / 2014 / Ubiquitin–Proteasome System in Spermatogenesis / Advances in Experimental Medicine and Biology 759:181~213
Bharathi Suresh / 2015 / The role of deubiquitinating enzymes in spermatogenesis / Cellular and Molecular Life Sciences 72(24):4711~4720
Takeshi Sato / 2004 / A close correlation in the expression patterns of Af-6 and Usp9x in Sertoli and granulosa cells of mouse testis and ovary / Reproduction 128(5):583~594
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