지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2021.2
- 수록면
- 64 - 77 (14page)
- DOI
- 10.5668/JEHS.2021.47.1.64
이용수
초록· 키워드
오류제보하기
Objective: Biological monitoring of trace elements in human blood samples has become an important indicator of the health environment. The purpose of this study was to detect and evaluate multiple metal items in blood samples based on ICP-MS, to perform comparative evaluation with the existing analysis method, and to develop and verify a new method.
Methods: 100 μL of whole blood from 80 healthy subjects was used to analyze ten metals (Sb, tAs, Cd, Pb, Mn, Hg, Mo, Ni, Se, Tl) using ICP-MS. Verification of the analysis method included calculation of linearity, accuracy, precision and detection limits. In addition, a comparative test with the conventional graphite furnace atomic absorption spectroscopy (GF-AAS) method was performed. In the case of Pb, Cd, and Hg in whole blood, cross-analysis between Pb, Cd, and Hg analysis methods was performed to confirm the difference between the existing method and the new method (ICP-MS).
Results: The coefficient of determination (R2 ) was 0.999 or higher in seven items and 0.995 or higher in three items. The Pb result showed that Pearson’s correlation coefficient was very high at 0.983, and the intraclass correlation coefficient was 0.966. The Cd result showed that Pearson's correlation coefficient was 0.917 between the existing method and the new analysis concentration value. Its intraclass correlation coefficient was 0.960, and there was no significant difference between the two groups. Hg had a low correlation at 0.687, and the intraclass correlation coefficient was 0.761, which was lower than that of Pb and Cd. The intra-day and inter-day accuracy of Pd and Cd were satisfactory, but Hg did not meet the criteria for both accuracy and precision when compared with the conventional analysis method.
Conclusion: This study can be meaningful in that it proposes a more efficient and feasible analysis method by verifying a blood heavy metal concentration experiment using multiple simultaneous analyses. All samples were processed and analyzed using the new ICP-MS. It was confirmed that the agreement between the two methods was very high, with the agreement between the current and new methods being 0.769 to 0.998. This study proposes an efficient simultaneous methodology capable of analyzing multiple elements with small samples. In the future, studies of various applications and the reliability of ICP-MS analysis methods are required, and research on the verification of accurate, precise, and continuous analysis methods is required.
목차
등록된 정보가 없습니다.
참고문헌 (31)
참고문헌 신청
Nico Laur / 2020 / ICP-MS trace element analysis in serum and whole blood / PLOS ONE 15(5):e0233357
Angerer J / 2011 / Human biomonitoring assessment values : approaches and data requirements / Int J Hyg Environ Health 214(5):348~360
Kim S / 2015 / Application of biomonitoring to activities on environmental health and recommendations for Korean National Environmental Health Survey / The Korean Journal of Public Health 52(1):59~74
Lee JH / 2012 / Korea National Survey for environmental pollutants in the human body 2008 : heavy metals in the blood urine of the Korean population / Int J Environ Health 215(4):449~457
박충희 / 2014 / 국민환경보건기초조사의 현황 및 전망 / 한국환경보건학회지 40(1):1~9
Angerer J / 2011 / Human biomonitoring assessment values : approaches and data requirements / Int J Hyg Environ Health 214(5):348~360
Kim S / 2015 / Application of biomonitoring to activities on environmental health and recommendations for Korean National Environmental Health Survey / The Korean Journal of Public Health 52(1):59~74
Lee JH / 2012 / Korea National Survey for environmental pollutants in the human body 2008 : heavy metals in the blood urine of the Korean population / Int J Environ Health 215(4):449~457
박충희 / 2014 / 국민환경보건기초조사의 현황 및 전망 / 한국환경보건학회지 40(1):1~9
함께 읽어보면 좋을 논문
논문 유사도에 따라 DBpia 가 추천하는 논문입니다. 함께 보면 좋을 연관 논문을 확인해보세요!
-
국가 바이오모니터링 프로그램을 위한 소변 중 금속류 동시분석법 개발 및 검증
한국환경보건학회지
2019 .01
-
흑연로 원자 흡광 광도법과 유도 결합 플라즈마 질량 분석법을 이용한 혈중 납 농도 비교
한국환경보건학회지
2019 .01
-
흑연로 원자 흡광 광도기와 유도 결합 플라즈마 질량 분석기를 이용한 인체 혈중 카드뮴 농도 비교
한국환경보건학회지
2018 .01
-
글리터를 포함한 네일에나멜 제품의 유해금속 분석
한국환경보건학회지
2017 .01
-
The determination of contents of heavy metals and Pb isotopic ratio in airborne particulate matters (PM) using ICP-QQQ and MC-ICP-MS
환경독성보건학회 심포지엄 및 학술대회
2019 .10
-
Early immune response of neuronal cells (U87) to heavy metal Cd or Pb exposure
Environmental Analysis Health and Toxicology
2023 .03
-
뇌손상 환자에서 두개내압 상승의 평가
대한의사협회지
2023 .05
-
황사 발생과 대기 중 PM10, PM2.5, Cd, Pb 농도의 상관성
한국환경보건학회지
2020 .10
-
Intracranial Pressure Monitoring for Acute Brain Injured Patients: When, How, What Should We Monitor
Korean Journal of Neurotrauma
2023 .06
-
대구지역 유통 한약재의 유해금속 함량에 관한 연구
한국환경보건학회지
2017 .08
-
화장품 유형별 유해 중금속 함량 비교 연구
한국환경보건학회지
2019 .01
-
Studies on environmental pollutants between rice and cultivated habitat through heavy metal analysis
환경독성보건학회 심포지엄 및 학술대회
2019 .04
-
Handgrip Strength in the Korean Population: Normative Data and Cutoff Values
Annals of geriatric medicine and research
2019 .01
-
Relationship between Blood Mercury Concentration and Bone Mineral Density in Korean Men in the 2008–2010 Korean National Health and Nutrition Examination Survey
Korean Journal of Family Medicine
2016 .01
-
Trajectories of Handgrip Strength and Their Associations with Mortality among Older Adults in Korea: Analysis of the Korean Longitudinal Study of Aging
Korean Journal of Family Medicine
2021 .01
-
Korean research project on the integrated exposure assessment of hazardous substances for food safety
Environmental Analysis Health and Toxicology
2015 .12
-
LA- ICP/MS를 이용한 담수 어류 이석 내 금속 원소 농도 분석
환경독성보건학회 심포지엄 및 학술대회
2019 .10
-
Home Blood Pressure Monitoring Has Similar Effects on Office Blood Pressure and Medication Compliance as Usual Care
Korean Journal of Family Medicine
2019 .01
-
경기도내 어린이공원의 토양오염실태 연구
한국환경보건학회지
2017 .06
-
Extrinsic Acquisition of CD80 by Antigen-Specific CD8⁺ T Cells Regulates Their Recall Immune Responses to Acute Viral Infection
Immune Network
2019 .08
이 논문의 저자 정보
최근 본 자료
댓글(0)
0