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논문 기본 정보

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학술저널
저자정보
El-Rab Sanaa M. F. Gad (Department of Biotechnology Faculty of Science Taif University P.O. Box 888 Taif 21974 KSADepartmen) Basha Sakeenabi (Department of Preventive and Community Dentistry Faculty of Dentistry Taif University Taif 26571 Sa) Ashour Amal A. (Department of Oral and Maxillofacial Surgery and Diagnostic Sciences Oral Pathology Division Facult) Enan Enas Tawfik (Dental Biomaterials Faculty of Dentistry Taif University Taif 26571 Saudi ArabiaDental Biomaterials) Alyamani Amal Ahmed (Department of Biotechnology Faculty of Science Taif University P.O. Box 888 Taif 21974 KSA) Felemban Nayef H. (Preventive dentistry department Faculty of Dentistry Taif University Taif 26571 Saudi Arabia)
저널정보
한국미생물생명공학회 Journal of Microbiology and Biotechnology Journal of Microbiology and Biotechnology 제31권 제12호
발행연도
2021.12
수록면
1,656 - 1,666 (11page)
DOI
10.4014/jmb.2106.06008

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Dental pathogens lead to chronic diseases like periodontitis, which causes loss of teeth. Here, we examined the plausible antibacterial efficacy of copper nanoparticles (CuNPs) synthesized using Cupressus macrocarpa extract (CME) against periodontitis-causing bacteria. The antimicrobial properties of CME-CuNPs were then assessed against oral microbes (M. luteus. B. subtilis, P. aerioginosa) that cause periodontal disease and were identified using morphological/ biochemical analysis, and 16S-rRNA techniques. The CME-CuNPs were characterized, and accordingly, the peak found at 577 nm using UV?Vis spectrometer showed the formation of stable CME-CuNPs. Also, the results revealed the formation of spherical and oblong monodispersed CME-CuNPs with sizes ranged from 11.3 to 22.4 nm. The FTIR analysis suggested that the CME contains reducing agents that consequently had a role in Cu reduction and CME-CuNP formation. Furthermore, the CME-CuNPs exhibited potent antimicrobial efficacy against different isolates which was superior to the reported values in literature. The antibacterial efficacy of CME-CuNPs on oral bacteria was compared to the synergistic solution of clindamycin with CME-CuNPs. The solution exhibited a superior capacity to prevent bacterial growth. Minimum inhibitory concentration (MIC), minimum bactericidal concentration (MBC), and fractional inhibitory concentration (FIC) of CME-CuNPs with clindamycin recorded against the selected periodontal disease-causing microorganisms were observed between the range of 2.6?3.6 μg/ml, 4-5 μg/ml and 0.312-0.5, respectively. Finally, the synergistic antimicrobial efficacy exhibited by CME-CuNPs with clindamycin against the tested strains could be useful for the future development of more effective treatments to control dental diseases.
#Antibiotic #antimicrobial activity #copper nanoparticles #periodontal disease

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Global, regional, and national incidence, prevalence, and years lived with disability for 354 diseases and injuries for 195 countries and territories, 1990–2017: a systematic analysis for the Global Burden of Disease Study 2017 / Lancet 392:1789~8583 google schola Dias HB / 2016 / LED and low-level laser therapy association in tooth bleaching using a novel low concentration H2O2/N-doped TiO2 bleaching agent / Laser Phys 26:015602 google schola Petersen PE / 2012 / The global burden of periodontal disease: Towards integration with chronic disease prevention and control / Periodontol 2000(60):15~39 google schola Chen X / 2016 / Advanced biomaterials and their potential applications in the treatment of periodontal disease / Crit. Rev. Biotechnol 36:760~775 google schola Osorio R / 2016 / Bioactive polymeric nanoparticles for periodontal therapy / PLoS One 11:e0166217 google schola

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