지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 저널정보
- 한국미생물생명공학회 Journal of Microbiology and Biotechnology Journal of Microbiology and Biotechnology 제31권 제8호
- 발행연도
- 2021.8
- 수록면
- 1,175 - 1,182 (8page)
- DOI
- 10.4014/jmb.2106.06044
이용수
초록· 키워드
오류제보하기
We investigated the effect of bovine lactoferricin (Lfcin-B), a peptide derived from bovine lactoferrin, on activation of intestinal epithelial cells in IEC-6 intestinal cell, and protection against in vivo rotavirus (RV) infection. Treatment with Lfcin-B significantly enhanced the growth of IEC-6 cells and increased their capacity for attachment and spreading in culture plates. Also, Lfcin-B synergistically augmented the binding of IEC-6 cells to laminin, a component of the extracellular matrix (ECM). In the analysis of the intracellular mechanism related to Lfcin-B-induced activation of IEC-6 cells, this peptide upregulated tyrosine-dependent phosphorylation of focal adhesion kinase (FAK) and paxillin, which are intracellular proteins associated with cell adhesion, spreading, and signal transduction during cell activation. An experiment using synthetic peptides with various sequences of amino acids revealed that a sequence of 9 amino acids (FKCRRWQWR) corresponding to 17-25 of the N-terminus of Lfcin-B is responsible for the epithelial cell activation. In an in vivo experiment, treatment with Lfcin-B one day before RV infection effectively prevented RV-induced diarrhea and significantly reduced RV titers in the bowels of infected mice. These results suggest that Lfcin-B plays meaningful roles in the maintenance and repair of intestinal mucosal tissues, as well as in protecting against intestinal infection by RV. Collectively, Lfcin-B is a promising candidate with potential applications in drugs or functional foods beneficial for intestinal health and mucosal immunity.
목차
등록된 정보가 없습니다.
참고문헌 (3)
참고문헌 신청
이정림 / 2006 / Determination of the Minimal sequence of Bovine Lactoferricin Responsible for Apoptosis Induction in THP-1 Cells / Laboratory Animal Research 22(2):181~185
Hui Yang / 2018 / Ginsenoside-Rb2 and 20(S)-Ginsenoside-Rg3 from Korean Red Ginseng Prevent Rotavirus Infection in Newborn Mice / Journal of Microbiology and Biotechnology 28(3):391~396
유영춘 / 2013 / Protective effect of ginsenoside-Rb2 from Korean red ginseng on the lethal infection of haemagglutinating virus of Japan in mice / Journal of Ginseng Research 37(1):80~86
Hui Yang / 2018 / Ginsenoside-Rb2 and 20(S)-Ginsenoside-Rg3 from Korean Red Ginseng Prevent Rotavirus Infection in Newborn Mice / Journal of Microbiology and Biotechnology 28(3):391~396
유영춘 / 2013 / Protective effect of ginsenoside-Rb2 from Korean red ginseng on the lethal infection of haemagglutinating virus of Japan in mice / Journal of Ginseng Research 37(1):80~86
함께 읽어보면 좋을 논문
논문 유사도에 따라 DBpia 가 추천하는 논문입니다. 함께 보면 좋을 연관 논문을 확인해보세요!
-
Lactobacillus acidophilus Protects Irradiation-induced Intestinal Damage by Enhancing Intestinal Epithelial Cell Function
한국미생물학회 학술대회논문집
2022 .10
-
RV-23, a Melittin-Related Peptide with Cell-Selective Antibacterial Activity and High Hemocompatibility
Journal of Microbiology and Biotechnology
2016 .01
-
Recombinant Rv0753c Protein of Mycobacterium tuberculosis Induces Apoptosis Through Reactive Oxygen Species-JNK Pathway in Macrophages
JOURNAL OF BACTERIOLOGY AND VIROLOGY
2020 .12
-
Effect of soybean-derived low molecular weight bioactive peptide (Bio-Peptone®) on skin cell activation
한국분석과학회 학술대회
2019 .11
-
IPA and its precursors differently modulate the proliferation, differentiation, and integrity of intestinal epithelial cells
Nutrition Research and Practice
2023 .08
-
IPA and its precursors differently modulate the proliferation, differentiation, and integrity of intestinal epithelial cells
Nutrition Research and Practice
2023 .08
-
다양한 ECM 조건하에서의 세포막 미세영역 부위 국소접착인산화효소 활성의 단일세포 이미징 기반 분석
생명과학회지
2022 .02
-
Human Intestinal Organoid as a Platform to Study Intestinal Microbiota
한국미생물학회 학술대회논문집
2021 .08
-
Lipoteichoic Acid of Lactobacillus plantarum Inhibits Poly I:C-induced IL-8 Production in Porcine Intestinal Epithelial Cells
한국미생물학회 학술대회논문집
2017 .04
-
Erratum : Valeriana jatamansi Jones Inhibits Rotavirus-Induced Diarrhea via Phosphatidylinositol 3-Kinase/Protein Kinase B Signaling Pathway
Journal of Microbiology and Biotechnology
2024 .02
-
Protective Effects of a Novel Probiotic Strain of Lactobacillus plantarum JSA22 from Traditional Fermented Soybean Food Against Infection by Salmonella enterica Serovar Typhimurium
Journal of Microbiology and Biotechnology
2015 .01
-
Cross-talk between Mucin Degrading Bacteria and Intestinal Stem Cells Controls Epithelial Development
한국미생물학회 학술대회논문집
2021 .08
-
Curcumin utilizes the anti-inflammatory response pathway to protect the intestine against bacterial invasion
Nutrition Research and Practice
2015 .04
-
Curcumin utilizes the anti-inflammatory response pathway to protect the intestine against bacterial invasion
Nutrition Research and Practice
2015 .04
-
Cytotoxicity and inhibition cell growth assessment in lung epithelial cell A549 of cinnamaldehyde
한국분석과학회 학술대회
2017 .11
-
Lactobacillus casei LC01 Regulates Intestinal Epithelial Permeability through miR-144 Targeting of OCLN and ZO1
Journal of Microbiology and Biotechnology
2020 .01
-
KSHV Infection in Established B Cells Require Cell-associated Viruses
한국미생물학회 학술대회논문집
2016 .04
-
Ginsenoside-Rb2 and 20(S)-Ginsenoside-Rg3 from Korean Red Ginseng Prevent Rotavirus Infection in Newborn Mice
Journal of Microbiology and Biotechnology
2018 .01
-
Intestinal Th17 Cells Regulate Metabolic Homeostasis by Controlling Gut Microbiota
한국미생물학회 학술대회논문집
2018 .04
-
Bee Venom Decreases LPS-Induced Inflammatory Responses in Bovine Mammary Epithelial Cells
Journal of Microbiology and Biotechnology
2017 .01
이 논문의 저자 정보
최근 본 자료
댓글(0)
0