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논문 기본 정보

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학술저널
저자정보
Qiuke Hou (The First Affiliated Hospital of Guangzhou University of Chinese Medicine) Yongquan Huang (The Second Affiliated Hospital of Guangzhou University of Chinese Medicine) Yan Wang (The First Affiliated Hospital of Guangzhou University of Chinese Medicine) Liu Liao (The First Affiliated Hospital of Guangzhou University of Chinese Medicine) Zhaoyang Zhu (The First Affiliated Hospital of Guangzhou University of Chinese Medicine) Wenjie Zhang (The First Affiliated Hospital of Guangzhou University of Chinese Medicine) Yongshang Liu (The First Affiliated Hospital of Guangzhou University of Chinese Medicine) Peiwu Li (The First Affiliated Hospital of Guangzhou University of Chinese Medicine) Xinlin Chen (Guangzhou University of Chinese Medicine) Fengbin Liu (The First Affiliated Hospital of Guangzhou University of Chinese Medicine)
저널정보
한국미생물생명공학회 Journal of Microbiology and Biotechnology Journal of Microbiology and Biotechnology 제30권 제10호
발행연도
2020.1
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1,480 - 1,487 (8page)

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Our previous report determined that miR-144 is a key regulator of intestinal epithelial permeability in irritable bowel syndrome with diarrhea (IBS-D) rats. Recent evidence has shown that lactobacilli play an important role in the relief of IBS-D symptoms. However, few studies have addressed the mechanisms by which microRNAs and lactobacilli exert their beneficial effects on intestinal epithelial permeability. Hence, to elucidate whether miRNAs and lactobacilli play roles in intestinal epithelial barrier regulation, we compared miRNA expression levels in intestinal epithelial cells (IECs) under Lactobacillus casei (L. casei LC01) treatment. IECs and L. casei LC01 were co-cultured and then subjected to microRNA microarray assay. qRT-PCR, western blot and ELISA were used to detect the expression of occludin (OCLN) and zonula occludens 1 (ZO1/TJP1). The interaction between miRNAs and L. casei LC01 acting in IECs was investigated through transfection of RNA oligoribonucleotides and pcDNA 3.1 plasmid. The results are as follows: 1) L. casei LC01 decreased the expression of miR-144 and FD4 and promoted OCLN and ZO1 expression in IECs; 2) L. casei LC01 enhanced the barrier function of IECs via downregulation of miR-144 and upregulation of OCLN and ZO1; 3) Under L. casei LC01 treatment, OCLN and ZO1 overexpression could partially eliminate the promoting effect of miR-144 on intestinal permeability in IECs. Our results demonstrate that L. casei LC01 regulates intestinal permeability of IECs through miR-144 targeting of OCLN and ZO1. L. casei LC01 can be a possible therapeutic target for managing dysfunction of the intestinal epithelial barrier.
#miR-144 #intestinal epithelial permeability #lactobacilli #occludin (OCLN) #zonula occludens 1 (ZO1/TJP1)

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참고문헌 (29)

참고문헌 신청
Quigley E / 2009 / Gut permeability in irritable bowel syndrome : More leaks add to slightly inflamed bowel syndrome conspiracy theory / Gastroenterology 137:728~730 google schola Gracie DJ / 2017 / Irritable bowel syndrome-type symptoms are associated with psychological comorbidity, reduced quality of life, and health care use in patients with inflammatory bowel disease / Gastroenterology 153:324~325 google schola Spiller R / 2009 / Postinfectious irritable bowel syndrome / Gastroenterology 136:1979~1988 google schola Orr WC / 1997 / Sleep and gastric function in irritable bowel syndrome : derailing the braingut axis / Gut 41:390~393 google schola Botschuijver S / 2017 / Intestinal fungal dysbiosis is associated with visceral hypersensitivity in patients with irritable bowel syndrome and rats / Gastroenterology 153:1026~1039 google schola

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