지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 저널정보
- 한국약제학회 Journal of Pharmaceutical Investigation Journal of Pharmaceutical Investigation 제51권 제6호
- 발행연도
- 2021.11
- 수록면
- 701 - 714 (14page)
- DOI
- 10.1007/s40005-021-00540-0
이용수
초록· 키워드
오류제보하기
Purpose The present study aimed to develop a novel therapeutic approach for controlled delivery of exemestane (EXE) to cancer cells using nanostructured polymeric micelles.
Methods A simplex centroid design of experiment study was employed for optimizing the polymeric micelle formulation to achieve the desired critical quality attributes, including micelle size, drug loading (DL), encapsulation efficiency (EE), and critical micelle concentration (CMC). The oil-in-water (o/w) solvent evaporation method was used to prepare mixed micelles (MMs) of copolymers L121/F127/GL44 for encapsulating EXE. Profile analysis tensiometer methods were used to determine the CMC of the copolymer mixture. EXE-MMs, blank mixed micelles, and lyophilized mixed micelles (Lyp- EXE-MMs) were characterized for other key quality attributes, such as zeta potential, chemical interactions, and morphology.
Results The optimized ratio of L121/F127/GL44 was 1.98, 0.812, and 1.20, respectively, providing EXE-MMs with small micelle sizes (35.45 ± 1.20 nm), higher EE (89.75 ± 2.14%), and DL (5.85 ± 2.14%). EXE-encapsulated MMs exhibited an in vitro sustained release profile with improved cytotoxicity against MCF-7 cells than that with pure EXE. The cellular growth inhibitory concentration ( IC50) of EXE-MMs was 0.225 ± 0.124 μg/ml, while that of naive EXE was 7.58 ± 0.145 μg/ ml. Moreover, in vivo pharmacokinetic parameters of EXE micellar formulation showed significant improvement in Cmax and AUC (0?72 h), viz. 207.54 ± 18.65 ng/ml and 3530.77 ± 212.25 ng h/ml, respectively, suggesting enhanced bioavailability than that of pure EXE.
Conclusion EXE-MMs have a great potential for enhancing the bioavailability of EXE.
목차
등록된 정보가 없습니다.
참고문헌 (38)
참고문헌 신청
Agha M / 1992 / Experiments with mixtures / Appl Stat 41:216
Azum N / 2018 / Synergistic effect of an antipsychotic drug chlorpromazine hydrochloride with pluronic triblock copolymer: a physicochemical study / J Mol Liq 260:159~165
Bray F / 2018 / Global cancer statistics 2018: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries / CA Cancer J Clin 68:394~424
Brueggemeier RW / 2002 / Overview of the pharmacology of the aromatase inactivator exemestane / Breast Cancer Res Treat 74:177~185
Chumsri S / 2011 / Aromatase, aromatase inhibitors, and breast cancer / J Steroid Biochem Mol Biol 125:13~22
Azum N / 2018 / Synergistic effect of an antipsychotic drug chlorpromazine hydrochloride with pluronic triblock copolymer: a physicochemical study / J Mol Liq 260:159~165
Bray F / 2018 / Global cancer statistics 2018: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries / CA Cancer J Clin 68:394~424
Brueggemeier RW / 2002 / Overview of the pharmacology of the aromatase inactivator exemestane / Breast Cancer Res Treat 74:177~185
Chumsri S / 2011 / Aromatase, aromatase inhibitors, and breast cancer / J Steroid Biochem Mol Biol 125:13~22
함께 읽어보면 좋을 논문
논문 유사도에 따라 DBpia 가 추천하는 논문입니다. 함께 보면 좋을 연관 논문을 확인해보세요!
-
Exercise alleviates cisplatin-induced toxicity in the hippocampus of mice by inhibiting neuroinflammation and improving synaptic plasticity
The Korean Journal of Physiology & Pharmacology
2024 .03
-
Metabotropic Effect of Probiotic Supplementation and High-Intensity Interval Training in Menopause-Induced Metabolic Syndrome in Rats
대한폐경학회지
2023 .04
-
Combined Aerobic and Resistance Exercise Training Reduces Circulating Apolipoprotein J Levels and Improves Insulin Resistance in Postmenopausal Diabetic Women
Diabetes and Metabolism Journal
2020 .01
-
참옻 추출물의 MCF-7 인체 유방암 세포에서 증식 억제효과
대한한의학방제학회지
2016 .01
-
견갑골 안정화 운동이 청소년 야구선수의 견관절 근 기능 및 통증 완화에 미치는 영향
대한스포츠의학회지
2015 .01
-
Comparison of in Vitro Cytotoxicity and Apoptogenic Activity of Magnesium Chloride and Cisplatin as Conventional Chemotherapeutic Agents in the MCF-7 Cell Line
Asian Pacific journal of cancer prevention : APJCP
2016 .01
-
Apoptotic Effects of 6-Gingerol in Human Breast Cancer Cells
International Journal of Oral Biology
2015 .01
-
Glehnia littoralis Root Extract Induces G0/G1 Phase Cell Cycle Arrest in the MCF-7 Human Breast Cancer Cell Line
Asian Pacific journal of cancer prevention : APJCP
2015 .01
-
Effects of Metformin on Cell Kinetic Parameters of MCF-7 Breast Cancer Cells in Vitro
Asian Pacific journal of cancer prevention : APJCP
2015 .01
-
Isocryptotanshinone Induced Apoptosis and Activated MAPK Signaling in Human Breast Cancer MCF-7 Cells
Journal of Breast Cancer
2015 .01
-
Comparative Evaluation of Silibinin Effects on Cell Cycling and Apoptosis in Human Breast Cancer MCF-7 and T47D Cell Lines
Asian Pacific journal of cancer prevention : APJCP
2016 .01
-
Del-1 promotes the proliferation and migration of tamoxifen-resistant MCF7 breast cancer cells
대한외과학회 학술대회 초록집
2017 .11
-
Momordica cochinchinensis Aril Extract Induced Apoptosis in Human MCF-7 Breast Cancer Cells
Asian Pacific journal of cancer prevention : APJCP
2015 .01
-
Thyroglobulin 검사의 반응조건에 따른 결과 비교 분석
핵의학기술
2017 .01
-
Association of Vitamin D Level with Clinicopathological Features in Breast Cancer
Asian Pacific journal of cancer prevention : APJCP
2015 .01
-
SP1-induced lncRNA MCF2L-AS1 promotes cisplatin resistance in ovarian cancer by regulating IGF2BP1/IGF2/MEK/ERK axis
Journal of Gynecologic Oncology
2022 .11
-
Tamoxifen affects heme oxygenase-1 (HO-1) expression in MCF-7 human breast cancer cell line
대한외과학회 학술대회 초록집
2019 .10
-
Synergistic Effect of Flavonoids from Artocarpus heterophyllus Heartwoods on Anticancer Activity of Cisplatin Against H460 and MCF-7 Cell Lines
Natural Product Sciences
2019 .12
-
A Study on the Evaluation of Oral Malodor Reduction Effect of Zinc Citrate-Containing Dentifrice on Night Use
International Journal of Clinical Preventive Dentistry
2018 .01
-
Dioscin Decreases Breast Cancer Stem-like Cell Proliferation via Cell Cycle Arrest by Modulating p38 Mitogen-activated Protein Kinase and AKT/mTOR Signaling Pathways
대한암예방학회지
2021 .09
이 논문의 저자 정보
최근 본 자료
댓글(0)
0