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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 저널정보
- 한국약제학회 Journal of Pharmaceutical Investigation Journal of Pharmaceutical Investigation 제47권 제6호
- 발행연도
- 2017.11
- 수록면
- 575 - 581 (7page)
이용수
초록· 키워드
오류제보하기
A lot of polymeric oral dosage forms have been invented for suitable drug delivery and compliance of patient. Oral dissolving film (ODF) offers a comfortable way to enable drug administration. The purpose of this study was to develop an ODF using lidocaine, with moderate mechanical strength and thickness, fast disintegration time and local anesthetic effect. Hydroxypropyl methyl cellulose, sodium alginate, glycerin, sodium lauryl sulfate, polyvinylpyrrolidone and citric acid were used to build the polymeric film base of the ODF. The optimal composition was determined by changing the ratio of individual excipients.
The thickness was insignificantly varied in the range of 0.04 ± 0.01 to 0.06 ± 0.01 mm. On the other hand, the tensile strength was 1.23 ± 0.20 to 1.83 ± 0.30 N/cm2. Drug content in the films was evaluated and the values were 16 mg of lidocaine per each ODF (40 mg/strip). Lidocaine ODF formulation showed the release of 91.7% of lidocaine within 1 min and 96.3% of lidocaine in 5 min. These results suggested that lidocaine ODF was well prepared and showed the fast release of lidocaine.
목차
등록된 정보가 없습니다.
참고문헌 (17)
참고문헌 신청
Abdelbary A / 2014 / Pharmaceutical and pharmacokinetic evaluation of a novel fast dissolving film formulation of flupentixol dihydrochloride / AAPS Pharm Sci Tech 15:1603~1610
Acharjya SK / 2010 / Spectrophotometric methods for simultaneous estimation of flupentixol dihydrochloride and melitracen hydrochloride in combined tablet dosage form / J Chem Pharm Res 2:158~171
Bala R / 2013 / Orally dissolving strips: a new approach to oral drug delivery system / Int J Pharm Investig 3:67~76
Cilurzo F / 2008 / Fast dissolving films made of maltodextrins / Eur J Pharm Biopharm 70:895~900
Gowacka K / 2009 / Optimization of lidocaine application in tumescent local anesthesia / Pharmacol Rep 61:641~653
Acharjya SK / 2010 / Spectrophotometric methods for simultaneous estimation of flupentixol dihydrochloride and melitracen hydrochloride in combined tablet dosage form / J Chem Pharm Res 2:158~171
Bala R / 2013 / Orally dissolving strips: a new approach to oral drug delivery system / Int J Pharm Investig 3:67~76
Cilurzo F / 2008 / Fast dissolving films made of maltodextrins / Eur J Pharm Biopharm 70:895~900
Gowacka K / 2009 / Optimization of lidocaine application in tumescent local anesthesia / Pharmacol Rep 61:641~653
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