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학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2018.10
- 수록면
- 900 - 908 (9page)
- DOI
- 10.14348/molcells.2018.0294
이용수
초록· 키워드
오류제보하기
Insulin resistance is closely associated with metabolic diseases such as type 2 diabetes, dyslipidemia, hypertension and atherosclerosis. Thiazolidinediones (TZDs) have been developed to ameliorate insulin resistance by activation of peroxisome proliferator-activated receptor (PPAR) γ. Although TZDs are synthetic ligands for PPARγ, metabolic outcomes of each TZD are different. Moreover, there are lack of head-to-head comparative studies among TZDs in the aspect of metabolic outcomes. In this study, we analyzed the effects of three TZDs, including lobeglitazone (Lobe), rosiglitazone (Rosi), and pioglitazone (Pio) on metabolic and thermogenic regulation. In adipocytes, Lobe more potently stimulated adipogenesis and insulin-dependent glucose uptake than Rosi and Pio. In the presence of pro-inflammatory stimuli, Lobe efficiently suppressed expressions of pro-inflammatory genes in macrophages and adipocytes. In obese and diabetic db/db mice, Lobe effectively promoted insulin-stimulated glucose uptake and suppressed pro-inflammatory responses in epididymal white adipose tissue (EAT), leading to improve glucose intolerance. Compared to other two TZDs, Lobe enhanced beige adipocyte formation and thermogenic gene expression in inguinal white adipose tissue (IAT) of lean mice, which would be attributable to cold-induced thermogenesis. Collectively, these comparison data suggest that Lobe could relieve insulin resistance and enhance thermogenesis at low-concentration conditions where Rosi and Pio are less effective.
목차
등록된 정보가 없습니다.
참고문헌 (45)
참고문헌 신청
Ahmadian, M. / 2013 / $PPAR{\gamma}$ signaling and metabolism: the good, the bad and the future / Nat. Med. 99:557
Assim A Alfadda / 2017 / Endophilin A2: A Potential Link to Adiposity and Beyond / Molecules and Cells 40(11):855~863
Berria, R. / 2007 / Reduction in hematocrit and hemoglobin following pioglitazone treatment is not hemodilutional in Type II diabetes mellitus / Clin. Pharmacol. Therap. 82:275~281
Bouhlel, M.A. / 2007 / $PPAR{\gamma}$ activation primes human monocytes into alternative M2 macrophages with anti-inflammatory properties / Cell Metabol. 6:137~143
Carriere, A. / 2014 / Browning of white adipose cells by intermediate metabolites: an adaptive mechanism to alleviate redox pressure / Diabetes 63:3253~3265
Assim A Alfadda / 2017 / Endophilin A2: A Potential Link to Adiposity and Beyond / Molecules and Cells 40(11):855~863
Berria, R. / 2007 / Reduction in hematocrit and hemoglobin following pioglitazone treatment is not hemodilutional in Type II diabetes mellitus / Clin. Pharmacol. Therap. 82:275~281
Bouhlel, M.A. / 2007 /
Carriere, A. / 2014 / Browning of white adipose cells by intermediate metabolites: an adaptive mechanism to alleviate redox pressure / Diabetes 63:3253~3265
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