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학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2018.6
- 수록면
- 591 - 602 (12page)
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초록· 키워드
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Gastric cancer is the fifth most common type of malignancy worldwide, and the survival rate of patients with advanced-stage gastric cancer is low, even after receiving chemotherapy. Here, we validated neurotensin receptor 1 (NTSR1) as a potential therapeutic target in gastric cancer. We compared NTSR1 expression levels in sixty different gastric cancer-tissue samples and cells, as well as in other cancer cells (lung, breast, pancreatic, and colon), by assessing NTSR1 expression via semi-quantitative real-time reverse transcription polymerase chain reaction, immunocytochemistry and western blot. Following neurotensin (NT) treatment, we analyzed the expression and activity of matrix metalloproteinase-9 (MMP-9) and further determined the effects on cell migra-tion and invasion via wound-healing and transwell assays. Our results revealed that NTSR1 mRNA levels were higher in gastric cancer tissues than non-cancerous tissues. Both of NTSR1 mRNA levels and expression were higher in gastric cancer cell lines relative to levels observed in other cancer-cell lines. Moreover, NT treatment induced MMP-9 expression and activity in all cancer cell lines, which was significantly decreased following treatment with the NTSR1 antagonist SR48692 or small-interfering RNA targeting NTSR1. Furthermore, NT-mediated metastases was confirmed by observing epithelial-mesenchymal transition markers SNAIL and E-cadherin in gastric cancer cells. NT-mediated invasion and migration of gastric cancer cells were reduced by NTSR1 depletion through the Erk signaling. These findings strongly suggested that NTR1 constitutes a potential therapeutic target for the inhibition of gastric cancer inva-sion and metastasis.
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등록된 정보가 없습니다.
참고문헌 (46)
참고문헌 신청
Aalinkeel, R. / 2011 / Overexpression of MMP-9 contributes to invasiveness of prostate cancer cell line LNCaP / Immunol. Invest. 40:447~464
Abrahao-Machado, L.F. / 2016 / HER2 testing in gastric cancer: An update / World J. Gastroenterol. 22:4619~4625
Akter, H. / 2015 / Activation of matrix metalloproteinase-9 (MMP-9) by neurotensin promotes cell invasion and migration through ERK pathway in gastric cancer / Tumour Biol. 36:6053~6062
Al-Batran, S.E. / 2012 / The validation of matrix metalloproteinase-9 mRNA gene expression as a predictor of outcome in patients with metastatic gastric cancer / Ann. Oncol. 23:1699~1705
Alifano, M. / 2010 / Neurotensin receptor 1 determines the outcome of non-small cell lung cancer / Clin. Cancer Res. 16:4401~4410
Abrahao-Machado, L.F. / 2016 / HER2 testing in gastric cancer: An update / World J. Gastroenterol. 22:4619~4625
Akter, H. / 2015 / Activation of matrix metalloproteinase-9 (MMP-9) by neurotensin promotes cell invasion and migration through ERK pathway in gastric cancer / Tumour Biol. 36:6053~6062
Al-Batran, S.E. / 2012 / The validation of matrix metalloproteinase-9 mRNA gene expression as a predictor of outcome in patients with metastatic gastric cancer / Ann. Oncol. 23:1699~1705
Alifano, M. / 2010 / Neurotensin receptor 1 determines the outcome of non-small cell lung cancer / Clin. Cancer Res. 16:4401~4410
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