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학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2017.10
- 수록면
- 761 - 772 (12page)
- DOI
- 10.14348/molcells.2017.0104
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초록· 키워드
오류제보하기
Glioblastoma is the most frequent and most ag-gressive brain tumor in adults. Solute carrier family 8 member 2 (SLC8A2) is only expressed in normal brain, but not present in other human normal tissues or in gliomas. Therefore, we hy-pothesized that SLC8A2 might be a glioma tumor suppressor gene and detected the role of SLC8A2 in glioblastoma and explored the underlying molecular mechanism. The glioblas-toma U87MG cells stably transfected with the lentivirus plasmid containg SLC8A2 (U87MG-SLC8A2) and negative control (U87MG-NC) were constructed. In the present study, we found that the tumorigenicity of U87MG in nude mice was totally inhibited by SLC8A2. Overexpression of SLC8A2 had no effect on cell proliferation or cell cycle, but impaired the invasion and migration of U87MG cells, most likely through inactivating the extracellular signal-related kinases (ERK)1/2 signaling pathway, inhibiting the nuclear translocation and DNA binding activity of nuclear factor kappa B (NF-κB), reducing the level of matrix metalloproteinases (MMPs) and urokinase-type plasminogen activator (uPA)-its receptor (uPAR) system (ERK1/2-NF-κB-MMPs/uPA-uPAR), and altering the protein levels of epithelial to mesenchymal transitions (EMT)-associated proteins E-cardherin, vimentin and Snail. In addition, SLC8A2 inhibited the angiogenesis of U87MG cells, probably through combined inhibition of endothelium-dependent and endothelium-nondependent angiogenesis (vascular mimicry pattern). Totally, SLC8A2 serves as a tumor suppressor gene and inhibits invasion, angiogenesis and growth of glioblastoma.
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참고문헌 (47)
참고문헌 신청
Arbab, A. S. / 2015 / Vascular mimicry: the next big glioblastoma target / Biochem. Physiol 4
Berridge, M. J. / 2003 / Calcium signalling: dynamics, homeostasis and remodelling / Nat. Rev. Mol. Cell Biol 4:517~529
Chen, P. N. / 2005 / Silibinin inhibits cell invasion through inactivation of both PI3K-Akt and MAPK signaling pathways / Chemico-Biol. Int 156:141~150
Chintala, S. K. / 1999 / Matrix metalloproteinases and their biological function in human gliomas / Int. J. Dev. Neurosci 17:495~502
Claes, A. / 2007 / Diffuse glioma growth: a guerilla war / Acta Neuropathol 114:443~458
Berridge, M. J. / 2003 / Calcium signalling: dynamics, homeostasis and remodelling / Nat. Rev. Mol. Cell Biol 4:517~529
Chen, P. N. / 2005 / Silibinin inhibits cell invasion through inactivation of both PI3K-Akt and MAPK signaling pathways / Chemico-Biol. Int 156:141~150
Chintala, S. K. / 1999 / Matrix metalloproteinases and their biological function in human gliomas / Int. J. Dev. Neurosci 17:495~502
Claes, A. / 2007 / Diffuse glioma growth: a guerilla war / Acta Neuropathol 114:443~458
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