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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 저널정보
- 한국미생물생명공학회 Journal of Microbiology and Biotechnology Journal of Microbiology and Biotechnology 제26권 제2호
- 발행연도
- 2016.1
- 수록면
- 309 - 314 (6page)
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We first demonstrated that cordycepin inhibited cell growth and triggered apoptosis in U87MG cells with wild-type p53, but not in T98G cells with mutant-type p53. Western blot data revealed that the levels of procaspase-8, -3, and Bcl-2 were downregulated in cordycepintreated U87MG cells, whereas the levels of Fas, FasL, Bak, cleaved caspase-3, -8, and cleaved PARP were upregulated, indicating that cordycepin induces apoptosis by activating the death receptor-mediated pathway in U87MG cells. Cordycepin-induced apoptosis could be suppressed by only SB203580, a p38 MAPK-specific inhibitor. These results suggest that cordycepin triggered apoptosis in U87MG cells through p38 MAPK activation and inhibition of the Akt survival pathway.
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참고문헌 (13)
참고문헌 신청
Chang L / 2001 / Mammalian MAP kinase signaling cascades / Nature 410:37~40
Das A / 2008 / N-(4-Hydroxyphenyl)retinamide induced both differentiation and apoptosis in human glioblastoma T98G and U87MG cells / Brain Res 1227:207~215
Downward J / 1998 / Mechanisms and consequences of activation of protein kinase B/Akt / Curr. Opin. Cell Biol 10:262~267
Elmore S / 2007 / Apoptosis: a review of programmed cell death / Toxicol. Pathol 35:495~516
Kwon HY / 2013 / Triptolide-mediated apoptosis by suppression of focal adhesion kinase through extrinsic and intrinsic pathways in human melanoma cells / Evid. Based Complement. Altern. Med :172548
Das A / 2008 / N-(4-Hydroxyphenyl)retinamide induced both differentiation and apoptosis in human glioblastoma T98G and U87MG cells / Brain Res 1227:207~215
Downward J / 1998 / Mechanisms and consequences of activation of protein kinase B/Akt / Curr. Opin. Cell Biol 10:262~267
Elmore S / 2007 / Apoptosis: a review of programmed cell death / Toxicol. Pathol 35:495~516
Kwon HY / 2013 / Triptolide-mediated apoptosis by suppression of focal adhesion kinase through extrinsic and intrinsic pathways in human melanoma cells / Evid. Based Complement. Altern. Med :172548
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