지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2017.1
- 수록면
- 37 - 44 (8page)
이용수
초록· 키워드
오류제보하기
PDK1 is essential for T cell receptor (TCR)-mediated activation of NF-κB, and PDK1-induced phosphorylation of PKCθ is important for TCR-induced NF-κB activation. However, inverse regulation of PDK1 by PKCθ during T cell activation has not been investigated. In this study, we found that PKCθ is involved in human PDK1 phosphorylation and that its kinase activity is crucial for human PDK1 phosphorylation. Mass spectrometry analysis of wild-type PKCθ or of kinase-inactive form of PKCθ revealed that PKCθ induced phosphorylation of human PDK1 at Ser-64. This PKCθ-induced PDK1 phosphorylation positively regulated T cell activation and TCR-induced NF-κB activation. Moreover, phosphorylation of human PDK1 at Ser-64 increased the stability of human PDK1 protein. These results suggest that Ser-64 is an important phosphorylation site that is part of a positive feedback loop for human PDK1-PKCθ-mediated T cell activation.
목차
등록된 정보가 없습니다.
참고문헌 (19)
참고문헌 신청
Balendran, A. / 2000 / A 3-phosphoinositide-dependent protein kinase-1 (PDK1) docking site is required for the phosphorylation of protein kinase Czeta (PKCzeta ) and PKC-related kinase 2 by PDK1 / J. Biol. Chem. 275:20806~20813
Bhatt, D. / 2014 / Regulation of the NF-kappaBmediated transcription of inflammatory genes / Front. Immunol. 5:71
Casamayor, A. / 1999 / Phosphorylation of Ser-241 is essential for the activity of 3-phosphoinositide-dependent protein kinase-1: identification of five sites of phosphorylation in vivo / Biochem. J. 342(Pt 2):287~292
Jang-Eun Cho / 2010 / Mycobacterium tuberculosis-Induced Expression of Leukotactin-1 Is Mediated by the PI3-K/PDK1/Akt Signaling Pathway / Molecules and Cells 29(1):35~39
Eckerdt, F. / 2005 / Pololike kinase 1-mediated phosphorylation stabilizes Pin1 by inhibiting its ubiquitination in human cells / J. Biol. Chem. 280:36575~36583
Bhatt, D. / 2014 / Regulation of the NF-kappaBmediated transcription of inflammatory genes / Front. Immunol. 5:71
Casamayor, A. / 1999 / Phosphorylation of Ser-241 is essential for the activity of 3-phosphoinositide-dependent protein kinase-1: identification of five sites of phosphorylation in vivo / Biochem. J. 342(Pt 2):287~292
Jang-Eun Cho / 2010 / Mycobacterium tuberculosis-Induced Expression of Leukotactin-1 Is Mediated by the PI3-K/PDK1/Akt Signaling Pathway / Molecules and Cells 29(1):35~39
Eckerdt, F. / 2005 / Pololike kinase 1-mediated phosphorylation stabilizes Pin1 by inhibiting its ubiquitination in human cells / J. Biol. Chem. 280:36575~36583
함께 읽어보면 좋을 논문
논문 유사도에 따라 DBpia 가 추천하는 논문입니다. 함께 보면 좋을 연관 논문을 확인해보세요!
-
Regulations of Reversal of Senescence by PKC Isozymes in Response to 12-O-Tetradecanoylphorbol-13-Acetate via Nuclear Translocation of pErk1/2
Molecules and Cells
2016 .03
-
PKC-β modulates Ca2+ mobilization through Stim1 phosphorylation
Genes & Genomics
2022 .05
-
대응비교를 통한 가우시안 프로세스 회귀모형의 공분산 모수 선택법
Journal of The Korean Data Analysis Society
2022 .12
-
Best Proximity Point Theorems for Cyclic θ-φ-contraction on Metric Spaces
순수 및 응용수학
2022 .11
-
Dichloroacetate Inhibits the Proliferation of a Human Anaplastic Thyroid Cancer Cell Line via a p53-independent Pathway
생명과학회지
2018 .12
-
DNA-Dependent Protein Kinase Catalytic Subunit (DNA-PKcs): Beyond the DNA Double-Strand Break Repair
Molecules and Cells
2023 .04
-
Integrated Quantitative Phosphoproteomics and Cell-Based Functional Screening Reveals Specific Pathological Cardiac Hypertrophy-Related Phosphorylation Sites
Molecules and Cells
2021 .01
-
용매 특성에 따른 1,2-dioleoyl-sn-glycero-3-phosphocholine (DOPC) 분자에서 글리세롤 골격 구조에 대한 MD 시뮬레이션 연구
대한화학회지
2021 .06
-
Compound K attenuates stromal cell-derived growth factor 1 (SDF-1)-induced migration of C6 glioma cells
Nutrition Research and Practice
2016 .06
-
Compound K attenuates stromal cell-derived growth factor 1 (SDF-1)-induced migration of C6 glioma cells
Nutrition Research and Practice
2016 .06
-
L-FUZZY MAPPINGS AND COMMON FIXED POINT THEOREMS
Nonlinear Functional Analysis and Applications
2018 .12
-
Vps34 Phosphorylation is Important for Autophagy Activation in Saccharomyces cerevisiae
한국미생물학회 학술대회논문집
2015 .04
-
Glycogen Synthase Kinase-3 Interaction Domain Enhances Phosphorylation of SARS-CoV-2 Nucleocapsid Protein
Molecules and Cells
2022 .12
-
Effect of soybean-derived low molecular weight bioactive peptide (Bio-Peptone®) on skin cell activation
한국분석과학회 학술대회
2019 .11
-
Phosphatidylcholine regulates NF-κB activation in attenuation of LPS-induced inflammation: evidence from in vitro study
Animal cells and systems
2018 .01
-
EMPLOYING GENERALIZED (ψ,θ,φ)-CONTRACTION ON PARTIALLY ORDERED FUZZY METRIC SPACES WITH APPLICATIONS
순수 및 응용수학
2020 .01
-
Global Histidine Phosphoproteomics in Human Prostate Cancer Cells
Mass Spectrometry Letters
2020 .09
-
FILTERS OF BE-ALGEBRAS WITH RESPECT TO A CONGRUENCE
Journal of applied mathematics & informatics
2016 .01
-
Butyrate Ameliorates Lipopolysaccharide-induced Myopathy through Inhibition of JNK Pathway and Improvement of Mitochondrial Function in C2C12 Cells
생명과학회지
2021 .05
-
Actin Dysfunction Induces Cell Cycle Delay at G2/M with Sustained ERK and RSK Activation in IMR-90 Normal Human Fibroblasts
Molecules and Cells
2018 .03
이 논문의 저자 정보
최근 본 자료
댓글(0)
0