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논문 기본 정보

자료유형
학술저널
저자정보
Ham Jongho (Laboratory of Mucosal Immunology Department of Biomedical Sciences Seoul National University Colleg) 김지현 (Laboratory of Mucosal Immunology Department of Biomedical Sciences Seoul National University Colleg) Ko Young Gyun (Laboratory of Mucosal Immunology Department of Biomedical Sciences Seoul National University Colleg) Kim Hye Young (Laboratory of Mucosal Immunology Department of Biomedical Sciences Seoul National University Colleg)
저널정보
대한천식알레르기학회(구 대한알레르기학회) Allergy, Asthma & Immunology Research Allergy, Asthma & Immunology Research Vol.14 No.4
발행연도
2022.7
수록면
361 - 378 (18page)
DOI
10.4168/aair.2022.14.4.361

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Asthma, chronic obstructive pulmonary disease, and idiopathic pulmonary fibrosis are representative chronic respiratory diseases (CRDs). Although they differ in terms of disease presentation, they are all thought to arise from unresolved inflammation. Neutrophils are not only the first responders to acute inflammation, but they also help resolve the inflammation. Notably, emerging clinical studies show that CRDs are associated with systemic and local elevation of neutrophils. Moreover, murine studies suggest that airway-infiltrating neutrophils not only help initiate airway inflammation but also prolong the inflammation. Given this background, this review describes neutrophil-mediated immune responses in CRDs and summarizes the completed, ongoing, and potential clinical trials that test the therapeutic value of targeting neutrophils in CRDs. The review also clarifies the importance of understanding how neutrophils interact with other immune cells and how these interactions contribute to chronic inflammation in specific CRDs. This information may help identify future therapeutic strategies for CRDs.

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