L-Theanine-Treated Adipose-Derived Mesenchymal Stem Cells Alleviate the Cytotoxicity Induced by N-Nitrosodiethylamine in Liver

Lai Yun-Ju; Sung Yi-Ting; Lai Yi-An; Chen Li-Nian; Chen Tung-Sheng; Chien Chiang-Ting

doi:10.1007/s13770-022-00472-2

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자료유형: 학술저널

저자정보: Lai Yun-Ju (Department of Life Science National Taiwan Normal University) Sung Yi-Ting (Department of Life Science National Taiwan Normal University) Lai Yi-An (Department of Life Science National Taiwan Normal University) Chen Li-Nian (Department of Life Science National Taiwan Normal University) Chen Tung-Sheng (Department of Life Science National Taiwan Normal University) Chien Chiang-Ting (Department of Life Science National Taiwan Normal University)

저널정보: 한국조직공학과 재생의학회 조직공학과 재생의학 조직공학과 재생의학 제19권 제6호

발행연도: 2022.12

수록면: 1,207 - 1,221 (15page)

DOI: 10.1007/s13770-022-00472-2

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Background: Liver inflammation is the main cause of severe liver diseases, including liver fibrosis, steatohepatitis, cirrhosis and hepatocellular carcinoma. Cell therapy topics are receiving increasingly more attention. The therapeutic applications of mesenchymal stem cells (MSC) have become one of the most discussed issues. While other stem cells have therapeutic effects, they have only one or two clinical applications. MSCs are responsible for repairing a variety of tissue injuries. Moreover, MSCs could be derived from several sources, including adipose tissue. MSCs are usually more abundant and easier to obtain compared to other stem cells. Methods: To prove the concept that MSCs have homing ability to the injured tissue and assist in tissue repair, we examined the effects of intravenous injected adipose-derived mesenchymal stem cells (ADSCs) in a N-nitrosodiethylamine (DEN)-induced liver injury rat model. Results: The significant repairing ability of ADSCs was observed. The levels of fibrosis, apoptosis, and tumorigenesis in the DEN-injured liver tissues all decreased after ADSC treatment. Furthermore, to enhance the therapeutic effects of ADSCs, we pretreated them with L-theanine, which promotes the hepatocyte growth factor secretion of ADSC, and therefore improved the healing effects on injured liver tissue. Conclusion: ADSCs, especially L-theanine-pretreated ADSCs, have anti-inflammation, anti-apoptosis, and anti-tumorigenesis effects on the N-nitrosodiethylamine-induced liver injury rat model.

#Mesenchymal stem cell #Adipose tissue-derived stem cell #Cell therapy #Tissue repair #Liver inflammation

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