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자료유형
학술저널
저자정보
신철 (고려대학교) Regina E. Y. Kim (Korea University College of Medicine) Robert J. Thomas (Beth Israel Deaconess Medical Center Boston MA USA) 윤창호 (서울대학교병원) 이승구 (고려대학교) Robert D. Abbott (Korea University College of Medicine)
저널정보
대한신경과학회 Journal of Clinical Neurology Journal of Clinical Neurology 제18권 제1호
발행연도
2022.1
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33 - 40 (8page)

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Background and Purpose While excessive daytime sleepiness can predate Parkinson’s dis ease in late-life, its association with parkinsonian-like (P-L) symptoms in middle age are un known. Since neurodegeneration can appear decades before a diagnosis of Parkinson’s disease, identifying clinical features associated with this early progression is important. The purpose of this study was to determine the association of daytime sleepiness with P-L symptoms in a population-based sample of middle-aged Korean adults. Methods During 2013 and 2014, daytime sleepiness and P-L symptoms were assessed in 2,063 males and females aged 50–64 years who were participating in the Korean Genome and Epidemiology Study. The severity of daytime sleepiness was quantified by the score on the Ep worth Sleepiness Scale (ESS). Self-reported P-L symptoms included nine motor disorders commonly associated with Parkinson’s disease. Participants with parkinsonism and related conditions are excluded. Results The prevalence of excessive daytime sleepiness (ESS score >10) was 7.0%. The fre quencies of P-L symptoms ranged from 0.5% (for “trouble buttoning buttons”) to 18.4% (for “handwriting smaller than it once was”). After adjustment for covariates and multiple testing, the relative odds of P-L symptoms comparing the 80th and 20th percentiles of ESS scores was 1.6 (p=0.001) for “voice is softer than it once was,” 2.1 (p<0.001) for “balance when walking is poor,” and 1.5 (p=0.002) for “loss of facial expression.” The prevalence of excessive daytime sleep iness increased from 6.3% to 19.8% when the number of symptoms increased from zero to three (p=0.004). Conclusions In Korean adults aged 50–64 years, daytime sleepiness is significantly associated with P-L symptoms. Whether coexisting daytime sleepiness and P-L symptoms predate extrapy ramidal and other impairments in later life warrants further investigation.

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