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논문 기본 정보

자료유형
학술저널
저자정보
Hyeon Hui Kang (Department of Internal Medicine Ulsan University Hospital University of Ulsan College of Medicine) Chul-Hyun Lim (Department of Internal Medicine College of Medicine The Catholic University of Korea Seoul Korea) Jung Hwan Oh (Department of Internal Medicine College of Medicine The Catholic University of Korea Seoul Korea) Min-Jae Cho (Department of Internal Medicine College of Medicine The Catholic University of Korea Seoul Korea) Sang Haak Lee (Department of Internal Medicine College of Medicine The Catholic University of Korea Seoul Korea)
저널정보
대한소화관운동학회(현 대한소화기능성질환.운동학회) Journal of Neurogastroenterology and Motility (JNM) Journal of Neurogastroenterology and Motility (JNM) Vol.27 No.2
발행연도
2021.1
수록면
215 - 222 (8page)

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Background/AimsAs there is insufficient evidence for a relationship between gastroesophageal reflux disease (GERD) and obstructive sleep apnea (OSA), we investigated whether OSA diagnosed by polysomnography (PSG) is related to GERD. MethodsA total of 402 subjects was evaluated. Overnight PSG was performed and a few questionnaires on GERD, anxiety, depression, and daytime sleepiness were administered. An apnea-hypopnea index < 5 was the classification criterion for subjects without OSA. Subjects with heartburn or acid regurgitation at least once a week were classified as having GERD. ResultsAmong the 402 subjects, 318 had OSA and 84 did not. The prevalence of GERD was 12.9% among patients with OSA and 10.7% among those without (P = 0.590). The prevalence of GERD did not correlate with OSA severity (P = 0.474). Patients with OSA with GERD had higher Stanford Sleepiness Scale (P = 0.004), Epworth Sleepiness Scale (P = 0.001), and depression (P < 0.001) scores than patients with OSA without GERD. Subjects with nocturnal gastroesophageal reflux symptoms had a higher body mass index, waist-to-height ratio, and waist circumference-to-height index than those without symptoms. Multiple logistic regression showed that higher Epworth Sleepiness Scale and depression scores were independent factors associated with GERD in patients with OSA. ConclusionsThe prevalence of GERD in patients with OSA was 12.9%. The prevalence of GERD did not correlate with OSA severity. Daytime sleepiness and depression seem to be associated with GERD in patients with OSA, while nocturnal reflux symptoms seem to be related to obesity in OSA.
#Depression #Gastroesophageal reflux #Obesity #Polysomnography #Sleep apnea #obstructive

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참고문헌 (39)

참고문헌 신청
정혜경 / 2011 / Epidemiology of Gastroesophageal Reflux Disease in Asia: A Systematic Review / Journal of Neurogastroenterology and Motility (JNM) 17(1):14~27 dbpia Oh JH / 2016 / Gastroesophageal reflux disease : recent advances and its association with sleep / Ann N Y Acad Sci 1380:195~203 google schola Bortolotti M / 2006 / Obstructive sleep apnoea is improved by a prolonged treatment of gastrooesophageal reflux with omeprazole / Dig Liver Dis 38:78~81 google schola Regenbogen E / 2012 / Esophageal reflux disease proton pump inhibitor therapy impact on sleep disturbance : a systematic review / Otolaryngol Head Neck Surg 146:524~532 google schola Leggett CL / 2014 / Obstructive sleep apnea is a risk factor for Barrett’s esophagus / Clin Gastroenterol Hepatol 12:583~588 google schola

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