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학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2022.6
- 수록면
- 85 - 93 (9page)
- DOI
- 10.17642/jcc.27.2.4
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초록· 키워드
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The intestine digests the food we eat and regulates the absorption of nutrients as well protect the body from external antigen or toxic substances. This barrier function become abnormal during inflammation. In this study, we confirmed the anti-inflammatory and epithelial barrier protective properties of acetylated distarch adipate (ADSP) in human-derived intestinal epithelial cells. ADSP showed a significant increase in cell viability with pro-inflammatory cytokine treatment and non-treatment. IL-6 and IL-1β significantly decreased with ADSP treatment as compared to the inflammation-induced group, while IL-8 didn’t show significant change. After confirming that ADSP significantly reduces the epithelial monolayer integrity damage and increased permeability induced by TNF-α and IFN-γ, we confirmed the change in expression amount of tight junction with immunofluorescence and western blotting. Our results contributed to the study of the bioactivity of ADSP, which is widely used as a food additive, and indicated its potential as an agent for inflammatory bowel disease.
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