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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2019.1
- 수록면
- 84 - 89 (6page)
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초록· 키워드
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Intestinal epithelial barrier plays an important role to regulate para-cellular transport of water, nutrients and ions and to defend against toxic agents and pathogens as a first barrier. Therefore, maintaining barrier integrity is required to enhance entire gut health. Curcuma longa L. (Turmeric) is a well-known natural product with its outstanding antioxidant and anti-inflammatory properties. However, an aerial part of turmeric such as leaves has been wasted as a byproduct, even though it has a bioactive property. In order to prepare the turmeric leaf polysaccharide fraction (TPF), turmeric leaf water extract was dialyzed with 12~14 kD membrane (MW cut off 12,000) and precipitated with ethanol. A prebiotic activity score of TPF was measured with Lactobacillus plantarum and L.paracasi subsp. tolerans, and compared with that of control, fructooligosaccharides (FOS) and inulin. The score of TPF (1.003 ± 0.197, 0.620 ± 0.143) was higher than that of control (0.168 ± 0.026, 0.187 ± 0.120), and similar to that of FOS (1.138 ± 0.281, 0.938 ± 0.065) and inulin (0.658 ± 0.181, 0.628 ± 0.160). To investigate the effects of TPF on intestinal barrier integrity, the effect of TPF on tight junction was measured in TNF-α induced Caco-2 cells. The result shows that trans-epithelial electrical resistance of TPF treated group was maintained relatively constant until 72 hr at 70.38%, comparingwith that of control group as 28.07%. In addition, TPF significantly increased the expression of tight junction-related proteins such as ZO-1 and Occludin. Taken together, our study demonstrates the prebiotic activity and protective effect of a polysaccharidefraction of turmeric leaf on intestinal epithelial barrier functions.
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참고문헌 (17)
참고문헌 신청
Chen, X. M / 2017 / Flavonoid composition of orange peel extract ameliorates alcoholinduced tight junctiondysfunction in Caco-2 monolayer / Food. Chem. Toxicol 105:398~406
Ying, W / 2014 / Effects of alcohol on intestinal epithelial barrier permeability and expression of tight junction-associated proteins / Mol. Med. Rep 9:2352~2356
Eleonora, C / 2017 / Anthocyanins inhibit tumor necrosis alpha-induced loss of Caco-2 cell barrier integrity / Food. Funct 8:2915~2923
Thomas, Y. M / 2005 / Mechanism of TNF-α modulation of Caco-2 intestinal epithelial tight junction barrier; role of myosin light-chain kinase protein expression / Am. J. Physiol. Gastrointest. Liver. Physiol 288:422~430
Rana, A-S / 2015 / TNF-α Modulation of Intestinal Tight JunctionPermeability Is Mediated by NIKIKK-α Axis Activation of the Canonical NF-κB Pathway / Am. J. Pathol 186:1151~1165
Ying, W / 2014 / Effects of alcohol on intestinal epithelial barrier permeability and expression of tight junction-associated proteins / Mol. Med. Rep 9:2352~2356
Eleonora, C / 2017 / Anthocyanins inhibit tumor necrosis alpha-induced loss of Caco-2 cell barrier integrity / Food. Funct 8:2915~2923
Thomas, Y. M / 2005 / Mechanism of TNF-α modulation of Caco-2 intestinal epithelial tight junction barrier; role of myosin light-chain kinase protein expression / Am. J. Physiol. Gastrointest. Liver. Physiol 288:422~430
Rana, A-S / 2015 / TNF-α Modulation of Intestinal Tight JunctionPermeability Is Mediated by NIKIKK-α Axis Activation of the Canonical NF-κB Pathway / Am. J. Pathol 186:1151~1165
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