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학술저널
저자정보
Ikuo Konishi (National Hospital Organization Kyoto Medical Center) Kaoru Abiko (National Hospital Organization Kyoto Medical Center) Takuma Hayashi (Clinical Research Center National Hospital Organization Kyoto Medical Center Kyoto Japan) Koji Yamanoi (Department of Gynecology and Obstetrics Kyoto University Graduate School of Medicine Kyoto Japan) Ryusuke Murakami (Kyoto University) Ken Yamaguchi (Kyoto University) Junzo Hamanishi (Kyoto University) Tsukasa Baba (Iwate Medical University School of Medicine) Noriomi Matsumura (Department of Obstetrics and Gynecology Kindai University Faculty of Medicine Osaka Japan) Masaki Mandai (Kyoto University Graduate School of Medicine) Kyoto Study Group for Ovarian Cancer Research (Kyoto Study Group for Ovarian Cancer Research)
저널정보
대한부인종양학회 Journal of Gynecologic Oncology Journal of Gynecologic Oncology Vol.33 No.5
발행연도
2022.9
수록면
1 - 17 (17page)
DOI
https://doi.org/10.3802/jgo.2022.33.e83

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Epithelial ovarian cancer remains the lethal gynecological malignancy in women. The representative histotype is high-grade serous carcinoma (HGSC), and most patients with HGSC present at advanced stages with peritoneal dissemination. Since the peritoneal dissemination is the most important factor for poor prognosis of the patients, complete exploration for its molecular mechanisms is mandatory. In this narrative review, being based on the clinical, pathologic, and genomic findings of HGSC, chromosomal instability and epigenetic dynamics have been discussed as the potential drivers for cancer development in the fallopian tube, acquisition of cancer stem cell (CSC)-like properties, and peritoneal metastasis of HGSC. The natural history of carcinogenesis with clonal evolution, and adaptation to microenvironment of peritoneal dissemination of HGSC should be targeted in the novel development of strategies for prevention, early detection, and precision treatment for patients with HGSC.

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