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논문 기본 정보

자료유형
학술저널
저자정보
Li Zhang (Harbin Institute of Technology) Gerile Oudeng (Shenzhen Children’s Hospital Futian Guangdong Shenzhen PR China.) Feiqiu Wen (Shenzhen Children’s Hospital Futian Guangdong Shenzhen PR China.) Guangfu Liao (Fujian Agriculture and Forestry University 350002 Fuzhou PR China.)
저널정보
한국생체재료학회 생체재료학회지 생체재료학회지 제26권 제4호
발행연도
2022.12
수록면
819 - 846 (28page)
DOI
https://doi.org/10.1186/s40824-022-00308-z

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Near-infrared-II (NIR-II, 1000–1700 nm) light-triggered photothermal therapy (PTT) has been regarded as a promis ing candidate for cancer treatment, but PTT alone often fails to achieve satisfactory curative outcomes. Hollow nanoplatforms prove to be attractive in the biomedical field owing to the merits including good biocompatibility, intrinsic physical-chemical nature and unique hollow structures, etc. On one hand, hollow nanoplatforms themselves can be NIR-II photothermal agents (PTAs), the cavities of which are able to carry diverse therapeutic units to realize multi-modal therapies. On the other hand, NIR-II PTAs are capable of decorating on the surface to combine with the functions of components encapsulated inside the hollow nanoplatforms for synergistic cancer treatment. Notably, PTAs generally can serve as good photoacoustic imaging (PAI) contrast agents (CAs), which means such kind of hollow nanoplatforms are also expected to be multifunctional all-in-one nanotheranostics. In this review, the recent advances of NIR-II hollow nanoplatforms for single-modal PTT, dual-modal PTT/photodynamic therapy (PDT), PTT/chemotherapy, PTT/catalytic therapy and PTT/gas therapy as well as multi-modal PTT/chemodynamic therapy (CDT)/chemotherapy, PTT/chemo/gene therapy and PTT/PDT/CDT/starvation therapy (ST)/immunotherapy are summarized for the first time. Before these, the typical synthetic strategies for hollow structures are presented, and lastly, potential challenges and perspectives related to these novel paradigms for future research and clinical translation are discussed.

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