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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2022.12
- 수록면
- 677 - 693 (17page)
- DOI
- https://doi.org/10.1186/s40824-022-00289-z
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초록· 키워드
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Cellular forces exerted on the extracellular matrix (ECM) during adhesion and migration under physiological and path ological conditions regulate not only the overall cell orphology but also nuclear deformation. Nuclear deformation can alter gene expression, integrity of the nuclear envelope, nucleus-cytoskeletal connection, chromatin rchitecture, and, in some cases, DNA damage responses. Although nuclear deformation is caused by the transfer of forces from the ECM to the nucleus, the role of intracellular rganelles in force transfer remains unclear and a challenging area of study. To elucidate nuclear mechanics, various factors such as appropriate biomaterial properties, rocessing route, cellular force measurement technique, and micromanipulation of nuclear forces must be understood. In the initial phase of this review, we focused on various engineered iomaterials (natural and synthetic extracellular matrices) and their manufacturing routes along with the properties required to mimic the tumor microenvironment. Furthermore, e discussed the principle of tools used to measure the cellular traction force generated during cell adhesion and migration, followed by recently developed techniques to auge nuclear mechanics. In the last phase of this review, we outlined the principle of traction force microscopy (TFM), challenges in the remodeling of traction forces, micro bead isplacement tracking algorithm, data transformation from bead movement, and extension of 2-dimensional TFM to multiscale TFM.
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