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학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2018.1
- 수록면
- 386 - 392 (7page)
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초록· 키워드
오류제보하기
Radiation therapy is highly effective for the management of pediatric malignant central nervous system (CNS) tumors including embryonal tumors. With the increment of long-term survivors from malignant CNS tumors, the radiation-related toxicities have become a major concern and we need to improve the treatment strategies to reduce the late complications without compromising the treatment outcomes. One of such strategies is to reduce the radiation dose to craniospinal axis or radiation volume and to avoid or defer radiation therapy until after the age of three. Another strategy is using particle beam therapy such as proton beams instead of photon beams. Proton beams have distinct physiologic advantages over photon beams and greater precision in radiation delivery to the tumor while preserving the surrounding healthy tissues. In this review, I provide the treatment principles of pediatric CNS embryonal tumors and the strategic improvements of radiation therapy to reduce treatment-related late toxicities, and finally introduce the increasing availability of proton beam therapy for pediatric CNS embryonal tumors compared with photon beam therapy.
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등록된 정보가 없습니다.
참고문헌 (31)
참고문헌 신청
Armstrong GT / 2010 / Long-term survivors of childhood central nervous system malignancies: the experience of the Childhood Cancer Survivor Study / Eur J Paediatr Neurol 14:298~303
Chi SN / 2004 / Feasibility and response to induction chemotherapy intensified with highdose methotrexate for young children with newly diagnosed high-risk disseminated medulloblastoma / J Clin Oncol 22:4881~4887
Chung CS / 2013 / Incidence of second malignancies among patients treated with proton versus photon radiation / Int J Radiat Oncol Biol Phys 87:46~52
Diller L / 2009 / Chronic disease in the Childhood Cancer Survivor Study cohort: a review of published findings / J Clin Oncol 27:2339~2355
Fangusaro J / 2008 / Intensive chemotherapy followed by consolidative myeloablative chemotherapy with autologous hematopoietic cell rescue (AuHCR) in young children with newly diagnosed supratentorial primitive neuroectodermal tumors (sPNETs): report of the Head Start I and II experience / Pediatr Blood Cancer 50:312~318
Chi SN / 2004 / Feasibility and response to induction chemotherapy intensified with highdose methotrexate for young children with newly diagnosed high-risk disseminated medulloblastoma / J Clin Oncol 22:4881~4887
Chung CS / 2013 / Incidence of second malignancies among patients treated with proton versus photon radiation / Int J Radiat Oncol Biol Phys 87:46~52
Diller L / 2009 / Chronic disease in the Childhood Cancer Survivor Study cohort: a review of published findings / J Clin Oncol 27:2339~2355
Fangusaro J / 2008 / Intensive chemotherapy followed by consolidative myeloablative chemotherapy with autologous hematopoietic cell rescue (AuHCR) in young children with newly diagnosed supratentorial primitive neuroectodermal tumors (sPNETs): report of the Head Start I and II experience / Pediatr Blood Cancer 50:312~318
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