지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2022.3
- 수록면
- 145 - 155 (11page)
- DOI
- https://doi.org/10.5468/ogs.21216
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초록· 키워드
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ObjectiveTo evaluate the clinical significance of soft markers for aneuploidy screening in Korean women.
MethodsWe retrospectively reviewed the medical records of 5,428 singleton pregnant women who underwent sonographyduring the second trimester at seven institutions in South Korea. We evaluated the prevalence of the following softmarkers: intracardiac echogenic focus, choroid plexus cysts, pyelectasis, echogenic bowel, and mild ventriculomegaly.
We developed best-fitted regression equations for the fetal femur and humerus length using our data and defineda short femur and humerus as both long bones below the fifth centile. The results of genetic testing and postnataloutcomes were investigated in patients who had been diagnosed with aforementioned soft markers.
ResultsThe median maternal age of our study population was 33 years, and the median gestational age at the time ofultrasonographic examination was 21 weeks. We detected soft markers in 10.0% (n=540) of fetuses: 9.3% (n=504)were isolated cases and 0.7% (n=36) of cases had two or more markers. We identified only two aneuploides (trisomy18, 46,XX,t[8;10][q22.1;p13]), of which one was clinically significant. We presented the neonatal outcomes of thefetuses with the respective soft markers. Preterm delivery, low birth weight, and small-for-gestational-age (SGA)were significantly more common in women with a shortened fetal femur (P<0.001, all). However, the presence of ashortened fetal humerus was not associated with those outcomes excluding SGA.
ConclusionSoft markers in second-trimester ultrasonography have limited use in screening for fetal aneuploidy in Korean women.
However, these markers can be used as a screening tool for adverse outcomes other than chromosomal abnormality.
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