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논문 기본 정보

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학술저널
저자정보
Jeong, Shin Ok (Department of Obstetrics and Gynecology, Cheil General Hospital and Women's Healthcare Center, Dankook University College of Medicine) Han, You Jung (Department of Obstetrics and Gynecology, Cheil General Hospital and Women's Healthcare Center, Dankook University College of Medicine) Lee, Si Won (Department of Obstetrics and Gynecology, Cheil General Hospital and Women's Healthcare Center, Dankook University College of Medicine) Kwak, Dong Wook (Department of Obstetrics and Gynecology, Cheil General Hospital and Women's Healthcare Center, Dankook University College of Medicine) Chung, Jin Hoon (Department of Obstetrics and Gynecology, Cheil General Hospital and Women's Healthcare Center, Dankook University College of Medicine) Ahn, Hyun Kyong (Department of Obstetrics and Gynecology, Cheil General Hospital and Women's Healthcare Center, Dankook University College of Medicine) Choi, June Seek (Department of Obstetrics and Gynecology, Cheil General Hospital and Women's Healthcare Center, Dankook University College of Medicine) Han, Jung Yeol (Department of Obstetrics and Gynecology, Cheil G) Kim, Moon Young Park, So Yeon Ryu, Hyun Mee Kim, Min Hyoung
저널정보
대한의학유전학회 Journal of genetic medicine Journal of genetic medicine 제12권 제2호
발행연도
2015.1
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92 - 95 (4page)

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Purpose: Increased maternal age is a major risk factor for chromosomal abnormalities. The maternal age-specific risk of fetal trisomy was theoretically calculated. We investigated the actual frequency of fetal trisomy between 16 and 24 gestational weeks in pregnant women over the age of 34 at delivery. Materials and Methods: We retrospectively, over a four-year period, reviewed the medical records of women with singleton pregnancies that started their antenatal care before the 10th week of pregnancy. Pregnant women aged 34 to 45 years at the time of delivery were enrolled and divided into groups of one-year intervals. We investigated the frequency of Down syndrome and all trisomies as a function of the maternal age and compared with the theoretical maternal-age-specific risk. Results: Of the 5,858 pregnant women enrolled in the study, the rate of trisomy 21 was 0.29% (17 cases). The observed frequencies of trisomy 21 in women with maternal ages of 35 years and 40 years were 1:1,116 and 1:141, respectively. The rate of all trisomies was 0.39% (23 cases). The observed frequencies of all trisomies in women with maternal ages of 35 years and 40 years were 1:372 and 1:56, respectively. Conclusion: The frequencies of Down syndrome and all trisomies were proportional to the maternal age. However, the observed frequencies of Down syndrome and all trisomies between the 16 and 24 gestational weeks were lower than the theoretical rates.
#Maternal age #Epidemiology #Trisomy

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참고문헌 (10)

참고문헌 신청
Hook EB / 1981 / Rates of chromosome abnormalities at different maternal ages / Obstet Gynecol 58:282~285 google schola Hook EB / 1983 / Chromosomal abnormality rates at amniocentesis and in live-born infants / JAMA 249:2034~2038 google schola 1995 / Chorionic villus sampling and amniocentesis: recommendations for prenatal counseling. Centers for Disease Control and Prevention / MMWR Recomm Rep 44:1~12 google schola Tabor A / 1986 / Randomised controlled trial of genetic amniocentesis in 4606 lowrisk women / Lancet 1:1287~1293 google schola Park IY / 2010 / Maternal age-specific rates of fetal chromosomal abnormalities at 16-20 weeks' gestation in Korean pregnant women >or=35 years of age / Fetal Diagn Ther 27:214~221 google schola

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