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논문 기본 정보

자료유형
학술저널
저자정보
Pak Chuiyong (Division of Pulmonology Department of Internal Medicine Ulsan University Hospital University of Uls) Clayton T. Cowl (Divisions of Preventive Occupational & Aerospace Medicine and Pulmonary & Critical Care Med) Kim Jin Hyoung (Division of Pulmonology Department of Internal Medicine Ulsan University Hospital University of Uls) Kang Byung Ju (Division of Pulmonology Department of Internal Medicine Ulsan University Hospital University of Uls) Lee Taehoon (Division of Pulmonology Department of Internal Medicine Ulsan University Hospital University of Uls) Jegal Yangjin (Division of Pulmonology Department of Internal Medicine Ulsan University Hospital University of Uls) Ra Seung Won (Division of Pulmonology Department of Internal Medicine Ulsan University Hospital University of Uls) Kim Yangho (Department of Occupational and Environmental Medicine Ulsan University Hospital University of Ulsan)
저널정보
대한의학회 Journal of Korean Medical Science Journal of Korean Medical Science Vol.37 No.44
발행연도
2022.11
수록면
1 - 14 (14page)
DOI
10.3346/jkms.2022.37.e319

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Background: Humidifier disinfectant-related lung injury (HDLI) is a severe form of toxic inhalational pulmonary parenchymal damage found in residents of South Korea previously exposed to specific guanidine-based compounds present in humidifier disinfectants (HD). HD-associated asthma (HDA), which is similar to irritant-induced asthma, has been recognized in victims with asthma-like symptoms and is probably caused by airway injury. In this study, diffusing capacity of the lung for carbon monoxide (DLCO) in individuals with HDA was compared to that in individuals with pre-existing asthma without HD exposure. Methods: We retrospectively compared data, including DLCO values, of 70 patients with HDA with that of 79 patients having pre-existing asthma without any known exposure to HD (controls). Multiple linear regression analysis and logistic regression analysis were performed to confirm the association between HD exposure and DLCO after controlling for confounding factors. The correlation between DLCO and several indicators related to HD exposure was evaluated in patients with HDA. Result: The mean DLCO was significantly lower in the HDA group than in the control group (81.9% vs. 88.6%; P = 0.021). The mean DLCO of asthma patients with definite HD exposure was significantly lower than that of asthma patients with lesser exposure (P for trend = 0.002). In multivariable regression models, DLCO in the HDA group decreased by 5.8%, and patients with HDA were 2.1-fold more likely to have a lower DLCO than the controls. Pathway analysis showed that exposure to HD directly affected DLCO values and indirectly affected its measurement through a decrease in the forced vital capacity (FVC). Correlation analysis indicated a significant inverse correlation between DLCO% and cumulative HD exposure time. Conclusion: DLCO was lower in patients with HDA than in asthma patients without HD exposure, and decreased FVC partially mediated this effect. Therefore, monitoring the DLCO may be useful for early diagnosis of HDA in patients with asthma symptoms and history of HD exposure.
#Humidifier Disinfectant #Lung #Diffusing Capacity #Exposure

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