지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2022.1
- 수록면
- 69 - 76 (8page)
- DOI
- 10.4082/kjfm.21.0110
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초록· 키워드
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Background: Osteoporosis is one of the most common diseases of the skeletal system, particularly occurring in older adults. Bisphosphonates are frequently used to treat osteoporosis and prevent bone fractures. Studies evalu-ating the association between treatment with bisphosphonate and the risk of atrial fibrillation have reported con-flicting results. This meta-analysis of observational studies was performed to assess this association.Methods: Databases were searched to find relevant observational studies, and the identified articles were selected according to the selection criteria. Sensitivity and subgroup analysis based on various confounding factors were performed. The pooled odds ratios (ORs) and 95% confidence intervals (CIs) for the risk of atrial fibrillation were estimated using a random-effects model.Results: We selected 12 studies, including four case-control and eight cohort studies, for the meta-analysis. Assess-ment of the estimated effect size yielded an OR of 1.171 (95% CI, 1.011?1.356; P=0.035), with substantial heteroge-neity (I2=84.74%, P<0.001). When the studies were excluded one-after-another, the pooled OR remained un-changed in only six studies. In addition, subgroup analyses found that treatment with bisphosphonates was posi-tively associated with the risk of atrial fibrillation in studies performed in Western countries (OR, 1.263; 95% CI, 1.092?1.462) and lower-quality studies (OR, 1.214; 95% CI, 1.035?1.423). No publication bias was observed.Conclusion: This meta-analysis showed that treatment with bisphosphonates may be associated with an increased risk of atrial fibrillation. Therefore, bisphosphonates should be carefully prescribed to patients at a high risk of atrial fibrillation.
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