지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
초록· 키워드
오류제보하기
Background: Epidemiology studies suggest that oral bisphosphonate may increase the risk of esophageal cancer. The present study aimed to investigate the association between exposure of oral bisphosphonate and risk of esophageal cancer. Methods: Using the nationwide medical claim database in South Korea, 2,167,955 subjects, who initiated osteoporosis treatment (oral bisphosphonate, intravenous bisphosphonate or raloxifene) or performed dual energy X-ray absorptiometry (DXA) between 2008 and 2012, were analyzed. Diagnosis of esophageal cancer was estimated from medical claim database.
Standardized incidence ratio (SIR) was estimated by comparing with incidence in the general population. Cox proportional hazards modeling was used to investigate age-adjusted hazard ratio (aHR) of esophageal cancer. Results: The present study included oral bisphosphonate group (N=1,435,846), comparator group 1 (intravenous bisphosphonate or raloxifene, N=78,363) and comparator group 2 (DXA, N=653,746). Mean age was 65.6±8.8 years and mean observation duration was 30.9±17.7 months. During 5,503,688 patient-years, 205 esophageal cancer incidences were observed. The annual incidence of esophageal cancer was 3.88, 4.21 and 3.30 for oral bisphosphonate group, comparator group 1 and comparator group 2, respectively. SIR of esophageal cancer was 1.24, 1.38 and 1.40 for oral bisphosphonate group, comparator group 1 and comparator group 2, respectively. Esophageal cancer risk of oral bisphosphonate group was not significantly different from comparator group 1 and comparator group 2 (aHR 0.87; 95% confidence interval [CI] 0.39-1.98 and aHR 0.94; 95% CI 0.68-1.30, respectively). Conclusions: The use of oral bisphosphonate was not associated with increased risk of esophageal cancer in real clinical practice using large scale nationwide database.
목차
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참고문헌 (21)
참고문헌 신청
Cardwell CR / 2010 / Exposure to oral bisphosphonates and risk of esophageal cancer / JAMA 304 : 657 ~ 663
Choi HJ / 2012 / Burden of osteoporosis in adults in Korea: a national health insurance database study / J Bone Miner Metab 30 : 54 ~ 58
Choi HJ / 2015 / Risk of fractures in subjects with antihypertensive medications : A nationwide claim study / Int J Cardiol 184 : 62 ~ 67
Chung DJ / 2013 / The prevalence and risk factors of vertebral fractures in Korean patients with type 2 diabetes / J Bone Miner Metab 31 : 161 ~ 168
Green J / 2010 / Oral bisphosphonates and risk of cancer of oesophagus, stomach, and colorectum: case-control analysis within a UK primary care cohort / BMJ 341 : c4444 ~
Choi HJ / 2012 / Burden of osteoporosis in adults in Korea: a national health insurance database study / J Bone Miner Metab 30 : 54 ~ 58
Choi HJ / 2015 / Risk of fractures in subjects with antihypertensive medications : A nationwide claim study / Int J Cardiol 184 : 62 ~ 67
Chung DJ / 2013 / The prevalence and risk factors of vertebral fractures in Korean patients with type 2 diabetes / J Bone Miner Metab 31 : 161 ~ 168
Green J / 2010 / Oral bisphosphonates and risk of cancer of oesophagus, stomach, and colorectum: case-control analysis within a UK primary care cohort / BMJ 341 : c4444 ~
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