지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
이용수
초록· 키워드
오류제보하기
Bisphosphonates have been widely used in the treatment of osteoporosis with robust data from many placebo-controlled trials demonstrating its efficacy in fracture risk reduction over 3 to 5 years of treatment. Although bisphosphonates are generally safe and well tolerated, concerns have emerged about the adverse effects related to its longterm use, including osteonecrosis of the jaw and atypical femur fractures. Because bisphosphonates are incorporated into the skeleton and continue to exert an anti-resorptive effect for a period of time after the discontinuation of drugs, the concept of a “drug holiday” has emerged, whereby the risk of adverse effects might be decreased while the patient still benefits from anti-fracture efficacy. As randomized clinical trial evidence is not yet available on who may qualify for a drug holiday, there is considerable controversy regarding the selection of candidates for the drug holiday and monitoring during a drug holiday, both of which should be based on individual assessments of risk and benefit.
This statement will provide suggestions for clinicians in South Korea on the identification of possible candidates and monitoring during a bisphosphonate drug holiday.
목차
등록된 정보가 없습니다.
참고문헌 (25)
참고문헌 신청
Bauer DC / 2014 / Fracture prediction after discontinuation of 4 to 5 years of alendro
Black DM / 2006 / Effects of continuing or stopping alendronate after 5 years of treatment : the Fracture Intervention Trial Long-term Extension(FLEX) : a randomized trial /
Black DM / 2012 / Continuing bisphosphonate treatment for osteoporosis--for whom and for how long? / N Engl J Med 366 : 2051 ~ 2053
Black DM / 2012 / The effect of 3 versus 6 years of zoledronic acid treatment of osteoporosis : a randomized extension to the HORIZON-Pivotal Fracture Trial(PFT) / J Bone Mi
Bonnick SL / 2006 / Monitoring osteoporosis therapy: bone mineral density, bone turnover markers, or both? / Am J Med 119 : S25 ~ S31
Black DM / 2006 / Effects of continuing or stopping alendronate after 5 years of treatment : the Fracture Intervention Trial Long-term Extension(FLEX) : a randomized trial /
Black DM / 2012 / Continuing bisphosphonate treatment for osteoporosis--for whom and for how long? / N Engl J Med 366 : 2051 ~ 2053
Black DM / 2012 / The effect of 3 versus 6 years of zoledronic acid treatment of osteoporosis : a randomized extension to the HORIZON-Pivotal Fracture Trial(PFT) / J Bone Mi
Bonnick SL / 2006 / Monitoring osteoporosis therapy: bone mineral density, bone turnover markers, or both? / Am J Med 119 : S25 ~ S31
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