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논문 기본 정보

자료유형
학술저널
저자정보
Ee Jean Lim (Singapore General Hospital) Khi Yung Fong (National University of Singapore) Jingqiu Li (Singapore General Hospital) Hong Hong Huang (Singapore General Hospital) Kenneth Chen (Singapore General Hospital) Kae Jack Tay (Singapore General Hospital) Christopher Wai Sam Cheng (Singapore General Hospital) Henry Sun Sien Ho (Singapore General Hospital) Nye Thane Ngo (Singapore General Hospital) John Shyi Peng Yuen (Singapore General Hospital)
저널정보
대한비뇨기과학회 Investigative and Clinical Urology Investigative and Clinical Urology Vol.63 No.2
발행연도
2022.3
수록면
151 - 158 (8page)
DOI
https://doi.org/10.4111/icu.20210373

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Purpose: To perform a retrospective review of the clinicopathological features of patients with conventional and non-conventional renal cell carcinoma (cRCC and ncRCC). Materials and Methods: A large prospectively maintained uro-oncological registry was accessed to extract clinicopathological data of patients diagnosed with renal tumors who subsequently underwent nephrectomy from 1990?2019. Demographics and operative parameters were extracted. Analyses of overall survival (OS) and cancer-specific survival (CSS) were performed using the Kaplan?Meier method. Cox proportional-hazards analysis was used to identify risk factors which influenced survival. Results: There were a total of 1,686 consecutive nephrectomies which was retrieved, with 1,286 cRCC and 400 ncRCC. The commonest ncRCC subtypes were papillary (n=198, 11.7%), clear cell papillary (n=50, 3.0%) and chromophobe (n=49, 2.9%) RCC. Kaplan?Meier estimates of OS were higher in cRCC (0.74; 95% confidence interval [CI], 0.71?0.78) than ncRCC (hazard ratio, 1.47; 95% CI, 1.16?1.87). Among individual subtypes, chromophobe RCC had the highest 5-year OS (0.90; 95% CI, 0.79?1.0). Among ncRCC subtypes, acquired cystic RCC demonstrated the highest association with end-stage renal failure and hypertension, with the highest CSS. MiT family translocation RCC had the youngest mean age at presentation (45.6±12.8 y) and excellent CSS. Factors associated with increased OS in the entire cohort included shorter operative time, partial nephrectomy and lower tumor stages. Conclusions: This study provides a comprehensive contemporary overview of ncRCCs which are yet poorly characterized, in comparison to cRCCs. Data from this study would contribute towards tailored patient counseling and healthcare resource planning.

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