지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 저널정보
- 대한외과학회 Annals of Surgical Treatment and Research Annals of Surgical Treatment and Research Vol.96 No.6
- 발행연도
- 2019.6
- 수록면
- 296 - 304 (9page)
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초록· 키워드
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Purpose: Previous studies have reported conflicting results regarding the prognostic value of tumor sidedness in colon cancer. We investigated the oncologic impact of tumor location and examined whether recurrence patterns were related to tumor sidedness in colon cancer patients.
Methods: We identified stage I–III colon adenocarcinoma patients from a prospective colorectal cancer registry at Severance Hospital, Seoul, Korea, who underwent complete mesocolic excision between 2005 and 2012. Adjusted hazard ratios (HRs) and 95% confidence intervals (CI) for predictors of cancer-specific survival (CSS), recurrence-free survival (RFS), and cumulative recurrence at specific anatomic sites were examined using Cox proportional hazard regression analysis.
Results: Overall, 1,912 patients, 1,077 (56.3%) with left-sided colon cancer (LCC), and 835 (43.7%) with right-sided colon cancer (RCC), at a median follow-up of 59 months, were eligible and included in the study. In univariate analysis, similar 5-year CSS and RFS were observed for LCC and RCC in the total patient population, and when stratified by stage for stage I and II patients. For stage III patients, an adjusted Cox regression analysis indicated that RCC patients had a higher risk of cancer-specific mortality (HR, 1.75; 95% CI, 1.07–2.86; P = 0.024) and recurrence (HR, 1.78; 95% CI, 1.22–2.60; P = 0.003). Furthermore, RCC was an independent predictor of peritoneal recurrence (HR, 1.86; 95% CI, 1.05–3.29; P = 0.031) in stage III patients.
Conclusion: RCC correlated with worse CSS and RFS than LCC. In stage III patients, RCC correlated with increased risk of peritoneal recurrence. The reasons for these differences remain to be investigated.
Methods: We identified stage I–III colon adenocarcinoma patients from a prospective colorectal cancer registry at Severance Hospital, Seoul, Korea, who underwent complete mesocolic excision between 2005 and 2012. Adjusted hazard ratios (HRs) and 95% confidence intervals (CI) for predictors of cancer-specific survival (CSS), recurrence-free survival (RFS), and cumulative recurrence at specific anatomic sites were examined using Cox proportional hazard regression analysis.
Results: Overall, 1,912 patients, 1,077 (56.3%) with left-sided colon cancer (LCC), and 835 (43.7%) with right-sided colon cancer (RCC), at a median follow-up of 59 months, were eligible and included in the study. In univariate analysis, similar 5-year CSS and RFS were observed for LCC and RCC in the total patient population, and when stratified by stage for stage I and II patients. For stage III patients, an adjusted Cox regression analysis indicated that RCC patients had a higher risk of cancer-specific mortality (HR, 1.75; 95% CI, 1.07–2.86; P = 0.024) and recurrence (HR, 1.78; 95% CI, 1.22–2.60; P = 0.003). Furthermore, RCC was an independent predictor of peritoneal recurrence (HR, 1.86; 95% CI, 1.05–3.29; P = 0.031) in stage III patients.
Conclusion: RCC correlated with worse CSS and RFS than LCC. In stage III patients, RCC correlated with increased risk of peritoneal recurrence. The reasons for these differences remain to be investigated.
목차
INTRODUCTION
METHODS
RESULTS
DISCUSSION
REFERENCES
참고문헌 (24)
참고문헌 신청
Meguid RA / 2008 / Is there a difference in survival between right-versus leftsided colon cancers / Ann Surg Oncol 15:2388~2394
Weiss JM / 2011 / Mortality by stage for right-versus left-sided colon cancer : analysis of surveillance, epidemiology, and end results--Medicare data / J Clin Oncol 29:4401~4409
Warschkow R / 2016 / Better survival in right-sided versus left-sided stage I-III colon cancer patients / BMC Cancer 16:554
Benedix F / 2010 / Comparison of 17, 641 patients with right-and leftsided colon cancer : differences in epidemiology, perioperative course, histology, and survival / Dis Colon Rectum 53:57~64
Lim DR / 2017 / Comparison of oncological outcomes of right-sided colon cancer versus left-sided colon cancer after curative resection:Which side is better outcome? / Medicine (Baltimore) 96:e8241
Weiss JM / 2011 / Mortality by stage for right-versus left-sided colon cancer : analysis of surveillance, epidemiology, and end results--Medicare data / J Clin Oncol 29:4401~4409
Warschkow R / 2016 / Better survival in right-sided versus left-sided stage I-III colon cancer patients / BMC Cancer 16:554
Benedix F / 2010 / Comparison of 17, 641 patients with right-and leftsided colon cancer : differences in epidemiology, perioperative course, histology, and survival / Dis Colon Rectum 53:57~64
Lim DR / 2017 / Comparison of oncological outcomes of right-sided colon cancer versus left-sided colon cancer after curative resection:Which side is better outcome? / Medicine (Baltimore) 96:e8241
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