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논문 기본 정보

자료유형
학술저널
저자정보
Wang Xing (Division of Animal Science Chonnam National University Gwangju 61186 Republic of Korea) Li Dingyun (Division of Animal Science Chonnam National University Gwangju 61186 Republic of Korea) Meng Ziyao (Division of Animal Science Chonnam National University Gwangju 61186 Republic of Korea) Kim Kiyeop (Division of Animal Science Chonnam National University Gwangju 61186 Republic of Korea) 오세종 (전남대학교)
저널정보
한국미생물생명공학회 Journal of Microbiology and Biotechnology Journal of Microbiology and Biotechnology 제32권 제3호
발행연도
2022.3
수록면
348 - 354 (7page)
DOI
10.4014/jmb.2109.09054

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Recent studies have shown that probiotics have health-promoting effects, particularly intestinal immune modulation. In this study, we focused on the immunomodulatory properties of Latilactobacillus curvatus BYB3, formerly called Lactobacillus curvatus, isolated from kimchi. In a mouse model of 14-day dextran sulfate sodium (DSS)-induced colitis, treatment with L. curvatus BYB3 significantly decreased the disease activity index, colon length, and weight loss. Moreover, histological analyses showed that L. curvatus BYB3 protected the structural integrity of the intestinal epithelial layer and mucin-secreting goblet cells from DSS-induced damage, with only slight infiltration by immune cells. To evaluate the molecular mechanisms underlying L. curvatus BYB3?driven inhibition of interleukin 6 production, possible in vivo anti-inflammatory effects of L. curvatus BYB3 were examined in the same mouse model. In addition, significantly lower levels of IL-6 and tumor necrosis factor receptor 1 upregulation were seen in the DSS+BYB3 group (compared to that in the DSS group). These results indicate that L. curvatus BYB3 exhibits health-promoting effects via immune modulation; and therefore, it can be used to treat various inflammatory diseases.

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