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논문 기본 정보

자료유형
학술저널
저자정보
Nam YoHan (Department of Microbiology College of Medicine Chung-Ang University Seoul 06974 Republic of Korea) Yoon Seokmin (Department of Microbiology College of Medicine Chung-Ang University Seoul 06974 Republic of KoreaLo) Baek Jihye (Department of Microbiology College of Medicine Chung-Ang University Seoul 06974 Republic of Korea) Kim Jong-Hwa (Department of Microbiology College of Medicine Chung-Ang University Seoul 06974 Republic of Korea) Park Miri (Lotte R&D Center Seoul 07594 Republic of Korea) Hwang KwangWoo (College of Pharmacy 2Chung‐Ang University Seoul 06974 Republic of Korea) Kim Wonyong (Department of Microbiology College of Medicine Chung-Ang University Seoul 06974 Republic of Korea)
저널정보
한국미생물생명공학회 Journal of Microbiology and Biotechnology Journal of Microbiology and Biotechnology 제32권 제3호
발행연도
2022.3
수록면
324 - 332 (9page)
DOI
10.4014/jmb.2111.11008

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The incidence of stress-related type 2 diabetes (stress-T2D), which is aggravated by physiological stress, is increasing annually. The effects of Lactobacillus, a key component of probiotics, have been widely studied in diabetes; however, studies on the effects of postbiotics are still limited. Here, we aimed to examine the mechanism through which heat-killed Lactiplantibacillus plantarum LRCC5314 (HK-LRCC5314) alleviates stress-T2D in a cold-induced stress-T2D C57BL/6 mouse model. HKLRCC5314 markedly decreased body weight gain, adipose tissue (neck, subcutaneous, and epididymal) weight, and fasting glucose levels. In the adipose tissue, mRNA expression levels of stress-T2D associated factors (NPY, Y2R, GLUT4, adiponectin, and leptin) and pro-inflammatory factors (TNF-α, IL-6, and CCL-2) were also altered. Furthermore, HK-LRCC5314 increased the abundance of Barnesiella, Alistipes, and butyrate-producing bacteria, including Akkermansia, in feces and decreased the abundance of Ruminococcus, Dorea, and Clostridium. Thus, these findings suggest that HK-LRCC5314 exerts protective effects against stress-T2D via gut microbiome modulation, suggesting its potential as a supplement for managing stress-T2D.

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