지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2022.9
- 수록면
- 1 - 11 (11page)
- DOI
- 10.1038/s12276-022-00847-4
이용수
초록· 키워드
오류제보하기
Receptor-interacting serine threonine protein kinase 1 (RIPK1) has emerged as a central molecular switch in controlling the balance between cell survival and cell death. The pro-survival role of RIPK1 in maintaining cell survival is achieved via its ability to induce NF-κB-dependent expression of anti-apoptotic genes. However, recent advances have identified the pro-death function of RIPK1: posttranslational modifications of RIPK1 in the tumor necrosis factor receptor 1 (TNFR1)-associated complex-I, in the cytosolic complex-IIb or in necrosomes regulate the cytotoxic potential of RIPK1, forming an early cell death checkpoint. Since the kinase activity of RIPK1 is indispensable in RIPK3- and MLKL-mediated necroptosis induction, while it is dispensable in apoptosis, a better understanding of this early cell death checkpoint via RIPK1 might lead to new insights into the molecular mechanisms controlling both apoptotic and necroptotic modes of cell death and help develop novel therapeutic approaches for cancer. Here, we present an emerging view of the regulatory mechanisms for RIPK1 activity, especially with respect to the early cell death checkpoint. We also discuss the impact of dysregulated RIPK1 activity in pathophysiological settings and highlight its therapeutic potential in treating human diseases.
목차
등록된 정보가 없습니다.
참고문헌 (0)
참고문헌 신청함께 읽어보면 좋을 논문
논문 유사도에 따라 DBpia 가 추천하는 논문입니다. 함께 보면 좋을 연관 논문을 확인해보세요!
-
Roles of RIPK3 in necroptosis, cell signaling, and disease
Experimental and Molecular Medicine
2022 .10
-
New role of E3 ubiquitin ligase in the regulation of necroptosis
BMB Reports
2016 .01
-
Inhibition of RIPK1-dependent regulated acinar cell necrosis provides protection against acute pancreatitis via the RIPK1/NF- κB/AQP8 pathway
Experimental and Molecular Medicine
2019 .01
-
The serine threonine kinase RIP3: lost and found
BMB Reports
2015 .01
-
Glutathione peroxidase-1 regulates ASK1-dependent apoptosis via interaction with TRAF2 in RIPK3-negative cancer cells
Experimental and Molecular Medicine
2021 .06
-
Necroptosis molecular mechanisms: Recent findings regarding novel necroptosis regulators
Experimental and Molecular Medicine
2021 .06
-
Entosis: the core mechanism and crosstalk with other cell death programs
Experimental and Molecular Medicine
2024 .04
-
Erratum : Inhibition of RIPK1-dependent regulated acinar cell necrosis provides protection against acute pancreatitis via the RIPK1/NF- κB/AQP8 pathway
Experimental and Molecular Medicine
2024 .02
-
HS-1371, a novel kinase inhibitor of RIP3-mediated necroptosis
Experimental and Molecular Medicine
2018 .01
-
The role of necroptosis in the treatment of diseases
BMB Reports
2018 .01
-
Molecular checkpoints controlling natural killer cell activation and their modulation for cancer immunotherapy
Experimental and Molecular Medicine
2017 .01
-
Dead cell phagocytosis and innate immune checkpoint
BMB Reports
2017 .01
-
Survivin protects fused cancer cells from cell death
BMB Reports
2017 .07
-
Regulation of RIP3 protein stability by PELI1-mediated proteasome-dependent degradation
BMB Reports
2018 .01
-
Regulation of Cell Death for Increased Production of Acid α -glucosidase in Rice Cell Cultures
한국생물공학회 학술대회
2016 .10
-
Optimal Checkpoint Times for a Computer System with Hardware and Software Failures
대한산업공학회 추계학술대회 논문집
2015 .11
-
Enhancement of paclitaxel-induced breast cancer cell death via the glycogen synthase kinase-3
BMB Reports
2016 .01
-
Human Cell Atlas and cell-type authentication for regenerative medicine
Experimental and Molecular Medicine
2020 .09
-
Apoptotic cell-derived exosomes: messages from dying cells
Experimental and Molecular Medicine
2020 .01
-
A Fully-Human Antibody Specifically Targeting a Membrane-Bound Fragment of CADM1 Potentiates the T Cell-Mediated Death of Human Small-Cell Lung Cancer Cells
한국생물공학회 학술대회
2023 .04
이 논문의 저자 정보
최근 본 자료
댓글(0)
0