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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2015.1
- 수록면
- 303 - 312 (10page)
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초록· 키워드
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Receptor-interacting protein kinase-3 (RIP3, or RIPK3) is an essential protein in the “programmed”, or “regulated” necrosis cell death pathway that is activated in response to death receptor ligands and other types of cellular stress. Programmed necrotic cell death is distinguished from its apoptotic counterpart in that it is not characterized by the activation of caspases; unlike apoptosis, programmed necrosis results in plasma membrane rupture, thus spilling the contents of the cell and triggering the activation of the immune system and inflammation.
Here we discuss findings, including our own recent data, which show that RIP3 protein expression is absent in many cancer cell lines. The recent data suggests that the lack of RIP3 expression in a majority of these deficient cell lines is due to methylation-dependent silencing, which limits the responses of these cells to pro-necrotic stimuli. Importantly, RIP3 expression may be restored in many cancer cells through the use of hypomethylating agents, such as decitabine. The potential implications of loss of RIP3 expression in cancer are explored, along with possible consequences for chemotherapeutic response.
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참고문헌 (73)
참고문헌 신청
Sun L / 2012 / Mixed lineage kinase domain-like protein mediates necrosis signaling downstream of RIP3 kinase / Cell 148:213~227
Wu JF / 2013 / Mlkl knockout mice demonstrate the indispensable role of Mlkl in necroptosis / Cell Res 23:994~1006
Murphy JM / 2013 / The pseudokinase MLKL mediates necroptosis via a molecular switch mechanism / Immunity 39:443~453
Wang HY / 2014 / Mixed Lineage Kinase Domain-like Protein MLKL Causes Necrotic Membrane Disruption upon Phosphorylation by RIP3 / Mol Cell 54:133~146
Cai ZY / 2014 / Plasma membrane translocation of trimerized MLKL protein is required for TNF-induced necroptosis / Nat Cell Biol 16:55~56
Wu JF / 2013 / Mlkl knockout mice demonstrate the indispensable role of Mlkl in necroptosis / Cell Res 23:994~1006
Murphy JM / 2013 / The pseudokinase MLKL mediates necroptosis via a molecular switch mechanism / Immunity 39:443~453
Wang HY / 2014 / Mixed Lineage Kinase Domain-like Protein MLKL Causes Necrotic Membrane Disruption upon Phosphorylation by RIP3 / Mol Cell 54:133~146
Cai ZY / 2014 / Plasma membrane translocation of trimerized MLKL protein is required for TNF-induced necroptosis / Nat Cell Biol 16:55~56
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