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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2018.1
- 수록면
- 219 - 224 (6page)
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Necroptosis is an emerging form of programmed cell death occurring via active and well-regulated necrosis, distinct from apoptosis morphologically, and biochemically. Necroptosis is mainly unmasked when apoptosis is compromised in response to tumor necrosis factor alpha. Unlike apoptotic cells, which are cleared by macrophages or neighboring cells, necrotic cells release danger signals, triggering inflammation, and exacerbating tissue damage. Evidence increasingly suggests that programmed necrosis is not only associated with pathophysiology of disease, but also induces innate immune response to viral infection. Therefore, necroptotic cell death plays both physiological and pathological roles. Physiologically, necroptosis induce an innate immune response as well as premature assembly of viral particles in cells infected with virus that abrogates host apoptotic machinery. On the other hand, necroptosis per se is detrimental, causing various diseases such as sepsis, neurodegenerative diseases and ischemic reperfusion injury. This review discusses the signaling pathways leading to necroptosis, associated necroptotic proteins with target-specific inhibitors and diseases involved. Several studies currently focus on protective approaches to inhibiting necroptotic cell death. In cancer biology, however, anticancer drug resistance severely hampers the efficacy of chemotherapy based on apoptosis. Pharmacological switch of cell death finds therapeutic application in drug- resistant cancers. Therefore, the possible clinical role of necroptosis in cancer control will be discussed in brief.
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참고문헌 (58)
참고문헌 신청
Jouan-Lanhouet S / 2012 / TRAIL induces necroptosis involving RIPK1/RIPK3- dependent PARP-1 activation / Cell Death Differ 19:2003~2014
Moriwaki K / 2015 / Differential roles of RIPK1 and RIPK3 in TNF-induced necroptosis and chemotherapeutic agentinduced cell death / Cell Death Dis 6:e1636
Miao B / 2009 / Methods to analyze cellular necroptosis / Methods Mol Biol 559:79~93
Hitomi J / 2008 / Identification of a molecular signaling network that regulates a cellular necrotic cell death pathway / Cell 135:1311~1323
Degterev A / 2008 / Identification of RIP1 kinase as a specific cellular target of necrostatins / Nat Chem Biol 4:313~321
Moriwaki K / 2015 / Differential roles of RIPK1 and RIPK3 in TNF-induced necroptosis and chemotherapeutic agentinduced cell death / Cell Death Dis 6:e1636
Miao B / 2009 / Methods to analyze cellular necroptosis / Methods Mol Biol 559:79~93
Hitomi J / 2008 / Identification of a molecular signaling network that regulates a cellular necrotic cell death pathway / Cell 135:1311~1323
Degterev A / 2008 / Identification of RIP1 kinase as a specific cellular target of necrostatins / Nat Chem Biol 4:313~321
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