지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2019.12
- 수록면
- 555 - 565 (11page)
이용수
초록· 키워드
오류제보하기
Development of a biomarker for predicting tumor-treatment efficacy is a matter of great concern, to reduce time, medical expense, and effort in oncology therapy. In a preclinical study, we hypothesized that the blood-flow parameter based on laser speckle flowmetry (LSF) could be a potential indicator to estimate the efficacy of breast-cancer treatment. To verify this hypothesis, a 13762-MAT-B-III rat breast tumor was grown in a dorsal skinfold window chamber applied to a nude mouse, and the change in blood flow rate (BFR) - or the speckle flow index (SFI) is used together as the same meaning in this manuscript -was longitudinally monitored during tumor growth and metronomic cyclophosphamide treatment. Based on the daily LSF angiogram, several BFR parameters (baseline SFI, normalized SFI, and ΔrBFR) were compared to tumor size in the normal, treated, and untreated tumor groups. Despite the incomplete tumor treatment, we found that the daily changes in all BFR parameters tended to have partially positive correlation with tumor size. Moreover, we observed that the changes in baseline SFI and normalized SFI responded one day earlier than the tumor shrinkage during chemotherapy. However, daily variations in the hypercapnia-induced ΔrBFR lagged tumor shrinkage by one day. This study would contribute not only to evaluating tumor vascular response to treatment, but also to monitoring blood-flow-mediated diseases (in brain, skin, and retina) by using LSF in preclinical settings.
목차
I. INTRODUCTION
II. METHODS
III. RESULTS
IV. DISCUSSION
V. CONCLUSION
REFERENCES
참고문헌 (46)
참고문헌 신청
R. L. Siegel / 2019 / Cancer statistics, 2019 / Ca-Cancer J. Clin 69:7~34
C. Zhou / 2007 / Diffuse optical monitoring of blood flow and oxygenation in human breast cancer during early stages of neoadjuvant chemotherapy / J. Biomed. Opt 12:051903
S. Ueda / 2019 / Early therapeutic prediction based on tumor hemodynamic response imaging : clinical studies in breast cancer with time-resolved diffuse optical spectroscopy / Appl. Sci 9:3
S. Lee / 2018 / Breast tumor hemodynamic response during a breath-hold as a biomarker to predict chemotherapeutic efficacy : preclinical study / J. Biomed. Opt 23:048001
H. S. Yazdi / 2017 / Mapping breast cancer blood flow index, composition, and metabolism in a human subject using combined diffuse optical spectroscopic imaging and diffuse correlation spectroscopy / J. Biomed. Opt 22:045003
C. Zhou / 2007 / Diffuse optical monitoring of blood flow and oxygenation in human breast cancer during early stages of neoadjuvant chemotherapy / J. Biomed. Opt 12:051903
S. Ueda / 2019 / Early therapeutic prediction based on tumor hemodynamic response imaging : clinical studies in breast cancer with time-resolved diffuse optical spectroscopy / Appl. Sci 9:3
S. Lee / 2018 / Breast tumor hemodynamic response during a breath-hold as a biomarker to predict chemotherapeutic efficacy : preclinical study / J. Biomed. Opt 23:048001
H. S. Yazdi / 2017 / Mapping breast cancer blood flow index, composition, and metabolism in a human subject using combined diffuse optical spectroscopic imaging and diffuse correlation spectroscopy / J. Biomed. Opt 22:045003
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