지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2018.2
- 수록면
- 1 - 6 (6page)
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초록· 키워드
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Our previous study showed that switching the inhaled gas from hypoxic gas to hyperoxic gas for 10 minutes increased tumor oxygenation and that the magnitude of oxyhemoglobin increase responded earlier than tumor volume change after chemotherapy. During 10 minutes of inhaled-oxygen modulation, oxyhemoglobin concentration first shows a rapid increase and then a slow but gradual increase, which has been fitted with a double-exponential equation in this study. Two amplitude values, amplitudes 1 and 2, respectively represent the magnitudes of rapid and slow increase of oxyhemoglobin. The trends of changes in amplitudes 1 and 2 were different, depending on tumor volume when chemotherapy started. However, both amplitudes 1 and 2 changed earlier than tumor volume, regardless of when chemotherapy was initiated. These results imply that by observing amplitude 1 changes post chemotherapy, we can reduce the time of a respiratory challenge from 10 minutes to less than 2 minutes, to see the chemotherapy response. We believe that by reducing the time of the respiratory challenge, we have taken a step forward to translating our previous study into clinical application.
목차
I. INTRODUCTION
II. METHODS
III. RESULTS
IV. DISCUSSION
V. CONCLUSION
REFERENCES
참고문헌 (16)
참고문헌 신청
A. W. Fyles / 1998 / Oxygenation predicts radiation response and survival in patients with cervix cancer / Radiother. Oncol. 48(2):149~156
R. H. Thomlinson / 1955 / The histological strucutre of some human lung cancers and the possible implications for radiotherapy / Br. J. Cancer 9:539~549
J. D. Chapman / 1991 / Oxygen dependency of tumor cell killing in vitro by light activated photofrin II / Radiat. Res. 126:73~79
B. Teicher / 1981 / Classification of antineoplastic agents by their selective toxicities toward oxygenated and hypoxic tumor cells / Cancer Res. 41:73~81
J. W. Denham / 1987 / Radiation therapy in hyperbaric oxygen for head and neck cancer at Royal Adelaide Hospital-1964 to 1980 / Int. J. Radiat. Oncol., Biol., Phys. 13:201~208
R. H. Thomlinson / 1955 / The histological strucutre of some human lung cancers and the possible implications for radiotherapy / Br. J. Cancer 9:539~549
J. D. Chapman / 1991 / Oxygen dependency of tumor cell killing in vitro by light activated photofrin II / Radiat. Res. 126:73~79
B. Teicher / 1981 / Classification of antineoplastic agents by their selective toxicities toward oxygenated and hypoxic tumor cells / Cancer Res. 41:73~81
J. W. Denham / 1987 / Radiation therapy in hyperbaric oxygen for head and neck cancer at Royal Adelaide Hospital-1964 to 1980 / Int. J. Radiat. Oncol., Biol., Phys. 13:201~208
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