지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2016.2
- 수록면
- 78 - 87 (10page)
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Red blood cells (RBCs) are customarily adhered to a bio-functionalised substrate to make them stationaryin interferometric phase-imaging modalities. This can make them susceptible to receive alterations in innatemorphology due to their own weight. Optical tweezers (OTs) often driven by Gaussian profile of a laserbeam is an alternative modality to overcome contact-induced perturbation but at the same time a steeplyfocused laser beam might cause photo-damage. In order to address both the photo-damage and substrateadherence induced perturbations, we were motivated to stabilize the RBC in OTs by utilizing a laser beamof ‘arbitrary intensity profile’ generated by a source having cavity imperfections per se. Thus the immobilizedRBC was investigated for phase-imaging with sinusoidal interferograms generated by a compact and robustMichelson interferometer which was designed from a cubic beam splitter having one surface coated withreflective material and another adjacent coplanar surface aligned against a mirror. Reflected interferogramsfrom bilayers membrane of a trapped RBC were recorded and analyzed. Our phase-imaging set-up is limitedto work in reflection configuration only because of the availability of an upright microscope. Due to RBC’smembrane being poorly reflective for visible wavelengths, quantitative information in the signal is weakand therefore, the quality of experimental results is limited in comparison to results obtained in transmissionmode by various holographic techniques reported elsewhere.
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등록된 정보가 없습니다.
참고문헌 (80)
참고문헌 신청
Y. L. Wang / 2008 / Methods in Cell Biology -Cell Mechanics / Elsevier Press
S. Suresh / 2006 / Mechanical response of human red blood cells in health and disease: some structure-property-function relationships / J. Mater. Res 21:1871~1877
Y. K. Park / 2008 / Refractive index maps and membrane dynamics of human red blood cells parasitized by Plasmodium falciparum / Proc. National Academy of Sciences 105:13730~13735
H. S. Byun / 2012 / Optical measurement of biomechanical properties of individual erythrocytes from a sickle cell patient / Acta Biomaterialia 8:4130~4138
K. K. Williams / 2010 / Hematology / McGraw-Hill Medical
S. Suresh / 2006 / Mechanical response of human red blood cells in health and disease: some structure-property-function relationships / J. Mater. Res 21:1871~1877
Y. K. Park / 2008 / Refractive index maps and membrane dynamics of human red blood cells parasitized by Plasmodium falciparum / Proc. National Academy of Sciences 105:13730~13735
H. S. Byun / 2012 / Optical measurement of biomechanical properties of individual erythrocytes from a sickle cell patient / Acta Biomaterialia 8:4130~4138
K. K. Williams / 2010 / Hematology / McGraw-Hill Medical
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