지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2022.10
- 수록면
- 119 - 130 (12page)
이용수
초록· 키워드
오류제보하기
Osteoclasts (OCs) are clinically important cells that resorb bone matrix. Accelerated bone destruction by OCs is closely linked to the development of metabolic bone diseases. In this study, we screened novel chemical inhibitors targeting OC differentiation to identify drug candidates for metabolic bone diseases. We identified that 1,3-dibenzyl-5-fluorouracil, also named OCI-101, is a novel inhibitor of osteoclastogenesis. The formation of multinucleated OCs is reduced by treatment with OCI-101 in a dose-dependent manner. OCI-101 inhibited the expression of OC markers via downregulation of receptor activator of NF-κB ligand and M-CSF signaling pathways. Finally, we showed that OCI-101 prevents ovariectomy-induced bone loss by suppressing OC differentiation in mice. Hence, these results demonstrated that OCI-101 is a good drug candidate for treating metabolic bone diseases.
목차
ABSTRACT
INTRODUCTION
MATERIALS AND METHODS
RESULTS
DISCUSSION
REFERENCES
참고문헌 (0)
참고문헌 신청함께 읽어보면 좋을 논문
논문 유사도에 따라 DBpia 가 추천하는 논문입니다. 함께 보면 좋을 연관 논문을 확인해보세요!
-
계혈등 에탄올 추출물의 RANKL 처리 RAW264.7 세포의 분화와 염증성 골 손실에 미치는 영향
대한한방내과학회지
2022 .12
-
Pro-inflammatory Cytokines Modulating Osteoclast Differentiation and Function
대한류마티스학회지
2016 .01
-
Effect of remifentanil on pre-osteoclast cell differentiation in vitro
Journal of dental anesthesia and pain medicine
2018 .01
-
The Role of Toll-Like Receptors in Osteoclastogenesis
대한골대사학회지
2020 .01
-
백작약 에탄올 추출물의 파골세포 분화 및 생성 억제 작용
동의생리병리학회지
2015 .02
-
백작약 에탄올 추출물의 파골세포 분화 및 생성 억제 작용
동의생리병리학회지
2015 .01
-
Extracts of Flavoparmelia sp. Inhibit Receptor Activator of Nuclear Factor-κB Ligand-Mediated Osteoclast Differentiation
대한골대사학회지
2019 .01
-
Acer tegmentosum Maxim Prevents Bone Loss by Inhibiting Osteoclastogenesis and Promoting Osteoblast Mineralization in Ovariectomized Mice
Natural Product Sciences
2020 .03
-
Biological characteristics of osteoporosis drugs: the effect of osteoblast–osteoclast coupling
International Journal of Oral Biology
2019 .01
-
강박장애 환자에서 강박증상차원에 부합하는 12문항 강박증상목록의 심리측정적 특성
대한불안의학회지
2023 .04
-
소청룡탕이 파골세포 분화억제와 골흡수에 미치는 영향
대한한의학회지
2017 .09
-
Osteoclasts: Crucial in Rheumatoid Arthritis
대한류마티스학회지
2016 .01
-
Dissecting Tumor-Stromal Interactions in Breast Cancer Bone Metastasis
Endocrinology and Metabolism
2016 .01
-
Bone Regeneration Using Collagenated Synthetic Bone Graft Attached to Collagen Membrane with 3,4-dihydroxy-L-phenylalanine (DOPA)
대한구강악안면임플란트학회지
2021 .01
-
Regulation of Osteoclast Differentiation by Cytokine Networks
Immune Network
2018 .02
-
The Time Course Changes in Bone Metabolic Markers after Administering the Anti-Receptor Activator of Nuclear Factor-Kappa B Ligand Antibody and Drug Compliance among Patients with Osteoporosis
Asian Spine Journal
2015 .01
-
Origin of Osteoclasts: Osteoclast Precursor Cells
대한골대사학회지
2023 .05
-
Updates on Paget’s Disease of Bone
Endocrinology and Metabolism
2022 .10
-
Piperlongumine suppressed osteoclastogenesis in RAW264.7 macrophages
International Journal of Oral Biology
2019 .01
-
Effects of Advanced Glycation End Products on Differentiation and Function of Osteoblasts and Osteoclasts
Journal of Korean Medical Science
2021 .09
이 논문의 저자 정보
최근 본 자료
댓글(0)
0