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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2019.9
- 수록면
- 159 - 164 (6page)
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Zanthoxylum Peel is widely used as a common spice for a variety of foods. In the orient, it has also been used as traditional agents for treating diseases such as indigestion. Recently, Zanthoxylum Peel has been reported to have anti-cancer activity, anti-microbial activity, and anti-inflammatory activity. Chemical components are known sanshool compounds and xanthoxylin. In this study, we were carried out to investigate the constituents of inhibiting a drug metabolizing enzyme CYP3A4 from Zanthoxylum Peel. CYP3A4 is known as an enzyme involved in drug metabolism as monooxygenase containing the heme. As a result of experiment, we found that bergapten (IC<SUB>50</SUB> = 18.21 μM) and quercetin (IC<SUB>50</SUB> = 17.27 μM) isolated from EtOAc extract of Zanthoxylum Peel showed remarkable CYP3A4-inhibiting activities. Structures of the isolated active compounds were established by chemical and spectroscopic means.
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Abstract
재료 및 방법
결과 및 고찰
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참고문헌 (39)
참고문헌 신청
식품의약안전처 / 2014 / 대한약전 제11개정, 의약품각조 제2부 / (주)약업신문 :53~54
이성우 / 1984 / 한국식품문화사 / 교문사 :60
이현용 / 2002 / 산초의 품질 평가 / 생약학회지 33(1):45~48
Fiho, V. C. / 1996 / Fungicide and funngiostatic effects of xanthoxylin / J. Ethnopharmacol 53:171~173
Jin, Y / 1999 / Effect of xanthoxylin on platelet aggregation in rabbits / Zhongguo Yaolixue Tongbao 15:186~187
이성우 / 1984 / 한국식품문화사 / 교문사 :60
이현용 / 2002 / 산초의 품질 평가 / 생약학회지 33(1):45~48
Fiho, V. C. / 1996 / Fungicide and funngiostatic effects of xanthoxylin / J. Ethnopharmacol 53:171~173
Jin, Y / 1999 / Effect of xanthoxylin on platelet aggregation in rabbits / Zhongguo Yaolixue Tongbao 15:186~187
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